*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EL8990000
CHEMICAL NAME : 2-Butanone, 3-((isopentyl)nitrosoamino)-
CAS REGISTRY NUMBER : 71016-15-4
BEILSTEIN REFERENCE NO. : 5924833
LAST UPDATED : 199612
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C9-H18-N2-O2
MOLECULAR WEIGHT : 186.29
WISWESSER LINE NOTATION : 1Y1&2NNO&Y1&V1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 3-((Isopentyl)nitrosoamino)-2-butanone
* Mambna
* N-3-Methylbutyl-N-1-methyl acetonylnitrosamine
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 21600 mg/kg/74W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
CCLCDY Zhonghua Zhongliu Zazhi. Chinese Journal of Oncology. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-
1978- Volume(issue)/page/year: 7,329,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8400 mg/kg/19W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
CCLCDY Zhonghua Zhongliu Zazhi. Chinese Journal of Oncology. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-
1978- Volume(issue)/page/year: 7,329,1985
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 19600 mg/kg/32W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
CCLCDY Zhonghua Zhongliu Zazhi. Chinese Journal of Oncology. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-
1978- Volume(issue)/page/year: 7,329,1985
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 27 gm/kg/74W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
CMJODS Chinese Medical Journal (Beijing, English Edition). (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-
1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year:
97,311,1984
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8400 mg/kg/19W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
CMJODS Chinese Medical Journal (Beijing, English Edition). (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-
1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year:
97,311,1984
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 2 gm/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 1,867,1980
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Human Lung
DOSE/DURATION : 1 gm/L
REFERENCE :
SSBSEF Scientia Sinica, Series B: Chemical, Biological, Agricultural,
Medical, and Earth Sciences (English Edition). (Scientific and Technical
Books Service Ltd., POB 197, London WC2N 4DE, UK) V.25- 1982-
Volume(issue)/page/year: 29,1192,1986
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 500 mg/L
REFERENCE :
SSBSEF Scientia Sinica, Series B: Chemical, Biological, Agricultural,
Medical, and Earth Sciences (English Edition). (Scientific and Technical
Books Service Ltd., POB 197, London WC2N 4DE, UK) V.25- 1982-
Volume(issue)/page/year: 25,738,1982
*** END OF RECORD ***