*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EM2600000
CHEMICAL NAME           : 2-Butenamide,
                          N-(2-(4-((3-cyclohexyl-2-imino-1-imidazolidinyl)sulfo
                          nyl)phenyl)ethyl)-, hydrochloride, (E)-
LAST UPDATED            : 198806
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C21-H29-N4-O3-S.Cl-H
MOLECULAR WEIGHT        : 454.06
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * CGP 11112 hydrochloride
   * Crotonamide,  
   N-(p-((3-cyclohexyl-2-imino-1-imidazolidinyl)sulfonyl)phenethyl)-,  
   hydrochloride
   *   1-(p-(2-(Crotonylamino)ethyl)phenylsulfonyl)-3-cyclohexyl-2-iminoimidazo
     lidine hydrochloride
   *   N-(p-((3-Cyclohexyl-2-imino-1-imidazolidinyl)sulfonyl)phenethyl)crotonam
     ide hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 34,247,1984
 
                            *** END OF RECORD ***