*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ES4316000
CHEMICAL NAME           : Butyramide,
                          2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-,
                          D-(+)-
CAS REGISTRY NUMBER     : 81-13-0
OTHER CAS REGISTRY NOS. : 17307-32-3
BEILSTEIN REFERENCE NO. : 1724947
REFERENCE               : 4-04-00-01652 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C9-H19-N-O4
MOLECULAR WEIGHT        : 205.29
WISWESSER LINE NOTATION : Q3MVYQX1&1&1Q
COMPOUND DESCRIPTOR     : Drug
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Bepanthen
   * Bepanthene
   * Bepantol
   * Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-
   * Cozyme
   * Dexpanthenol
   * D-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
   * D-P-A Injection
   * Ilopan
   * Motilyn
   * Panadon
   * Panthenol
   * D-Panthenol
   * D(+)-Panthenol
   * Panthoderm
   * Pantol
   * Pantothenol
   * d-Pantothenol
   * Pantothenyl alcohol
   * d-Pantothenyl alcohol
   * D(+)-Pantothenyl alcohol
   * Thenalton
   * Zentinic
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/4H
REACTION SEVERITY       : Mild
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 6(1),139,1987
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 ug
REACTION SEVERITY       : Mild
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 6(1),139,1987
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 6(1),139,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 14,43,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 73,292,1950
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 73,292,1950

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80472
       No. of Facilities: 1172 (estimated)
       No. of Industries: 7
       No. of Occupations: 16
       No. of Employees: 8069 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80472
       No. of Facilities: 2510 (estimated)
       No. of Industries: 4
       No. of Occupations: 7
       No. of Employees: 46519 (estimated)
       No. of Female Employees: 36944 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***