*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ES6550000
CHEMICAL NAME           : Butyric acid,
                          2-amino-4-(p-(bis(2-chloroethyl)amino)phenyl)-
CAS REGISTRY NUMBER     : 3688-35-5
BEILSTEIN REFERENCE NO. : 3215367
REFERENCE               : 4-14-00-01721 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C14-H20-Cl2-N2-O2
MOLECULAR WEIGHT        : 319.26
WISWESSER LINE NOTATION : QVYZ2R DN2G2G
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 2-Amino-4-(p-(bis(2-chloroethyl)amino)phenyl)butyric acid
   * Aminochlorambucil
   * alpha-Amino-gamma-(p-dichloroethylamino)phenylbutyric acid
   * alpha-Amino-gamma-p-(N,N-di-2-chloroethylamino)phenylbutyric acid
   * Benzenebutanoic acid, alpha-amino-4-(bis(2-chloroethyl)amino)-
   * CB 1385
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   5,192,1960
 
TYPE OF TEST            : LD10 - Lethal Dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 10,667,1974
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 160,228,1969

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal

 
                            *** END OF RECORD ***