*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ES7062000
CHEMICAL NAME           : Butyric acid, 4-amino-, methyl ester
CAS REGISTRY NUMBER     : 3251-07-8
BEILSTEIN REFERENCE NO. : 0635882
REFERENCE               : 3-04-00-01316 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C5-H11-N-O2
MOLECULAR WEIGHT        : 117.17
WISWESSER LINE NOTATION : Z3V01
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-Aminobutyric acid methyl ester
   * Butanoic acid, 4-amino-, methyl ester
   * GABA methyl ester
   * Methyl 4-aminobutanoate
   * Methyl gamma-aminobutyrate
   * Methyl 4-aminobutyrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 950 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - antipsychotic
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   13,70,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - antipsychotic
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   13,70,1965
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle weakness
   Skin and Appendages - hair
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   13,70,1965
 
                            *** END OF RECORD ***