*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ES7110000
CHEMICAL NAME           : Butyric acid, 2-amino-4-(methylselenyl)-, DL-
CAS REGISTRY NUMBER     : 2578-28-1
BEILSTEIN REFERENCE NO. : 1758204
REFERENCE               : 4-04-00-03216 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 29
MOLECULAR FORMULA       : C5-H11-N-O2-Se
MOLECULAR WEIGHT        : 196.13
WISWESSER LINE NOTATION : QVYZ2-SE-1
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * (+-)-2-Amino-4-(methylseleno)butanoic acid
   * Butanoic acid, 2-amino-4-(methylseleno)-, (+-)-
   * (+-)-Selenomethionine
   * Seleno-DL-methionine
   * dl-Selenomethionine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10680 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 17,171,1980
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 19600 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   45,207,1980
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - pig
DOSE/DURATION           : 77035 ug/kg/31D-C
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Blood - other changes
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   32,217,1996
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - duck
DOSE/DURATION           : 84 mg/kg/6W-C
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other oxidoreductases
   Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 27,263,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - duck
DOSE/DURATION           : 314 mg/kg/14W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Blood - pigmented or nucleated red blood cells
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other oxidoreductases
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 32,449,1991
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   10,75,1980
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   10,75,1980

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 0.2 mg(Se)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.2 mg(Se)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   3,224,1971

   OSHA PEL (Gen Indu):8H TWA 0.2 mg(Se)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 0.2 mg(Se)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 0.2 mg(Se)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 0.2 mg(Se)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-ARAB Republic of Egypt:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-AUSTRALIA:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-BELGIUM:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-DENMARK:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-FINLAND:TWA 0.1 mg(Se)/m3;STEL 0.3 mg(Se)/m3 JAN 1993
   
   OEL-GERMANY:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-HUNGARY:STEL 0.1 mg(Se)/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-POLAND:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-TURKEY:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

 
                            *** END OF RECORD ***