*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ET4730500
CHEMICAL NAME           : Butyric acid, 2-hydroxy-2-methyl-, 4-ester with
                          1,2,3,3a-beta,4,6a-beta,7,7a-alpha,10,11,
                          11a,11b-alpha-dodecahydro-1-alpha,2-alpha,4-beta,10-a
                          lpha,11-beta-pentahyd roxy-3-alpha,8,
                          11a-beta-trimethyl-5H-1,11c-beta-(epoxymethano)phenan
                          thro(10,1-bc)pyran-5- one
CAS REGISTRY NUMBER     : 1448-23-3
LAST UPDATED            : 199209
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C25-H36-O10
MOLECULAR WEIGHT        : 496.61
WISWESSER LINE NOTATION : T5 F6666/DS 3AAE S AX CO NOV IUTJ DQ GQ HQ J1
                          POVXQ2&1 R1 SQ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Glarubin
   * Glaucarubin
   * Glaucarubina
   * Glaumeba
   * alpha-Kirondrin
   * beta-Kirondrin
   * MK-53
   * Simarubaceae
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 8(2),172,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 114,307,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 8(2),172,1982
 
                            *** END OF RECORD ***