*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EV5790000
CHEMICAL NAME           : Caesium arsenate
CAS REGISTRY NUMBER     : 16331-85-4
OTHER CAS REGISTRY NOS. : 39406-88-7
LAST UPDATED            : 199610
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : As-H3-O4.Cs
MOLECULAR WEIGHT        : 274.86
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Arsenic acid cesium salt
   * Arsenic acid (H3AsO4), monocesium salt
   * Cesium dihydrogen arsenate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 335 mg/kg
TOXIC EFFECTS :
   Behavioral - wakefulness
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 21(1),29,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 116 mg/kg
TOXIC EFFECTS :
   Behavioral - wakefulness
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 21(1),29,1977
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13400 ug/m3/4H/4W-I
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 21(1),29,1977
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4960 ug/m3/4H/17W-I
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Liver - liver function tests impaired
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR.  Journal of the Academy of
   Medical Sciences of the USSR.  (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
   USSR)  V.1-    1946-  Volume(issue)/page/year: (8),10,1978
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4600 ug/m3/24H
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR.  Journal of the Academy of
   Medical Sciences of the USSR.  (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
   USSR)  V.1-    1946-  Volume(issue)/page/year: (8),10,1978
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 430 ug/m3/24H
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR.  Journal of the Academy of
   Medical Sciences of the USSR.  (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
   USSR)  V.1-    1946-  Volume(issue)/page/year: (8),10,1978

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO ARSENIC, INORGANIC-air:CA CL 0.002 mg(As)/m3/15M
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

 
                            *** END OF RECORD ***