*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EW1760000
CHEMICAL NAME : Calcium fluoride
CAS REGISTRY NUMBER : 7789-75-5
LAST UPDATED : 199712
DATA ITEMS CITED : 38
MOLECULAR FORMULA : Ca-F2
MOLECULAR WEIGHT : 78.08
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acid-spar
* Calcium difluoride
* Fluorspar
* Irtran 3
* Liparite
* Met-spar
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4250 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy of
Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR) V.1- 1946- Volume(issue)/page/year: (2),28,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and
Development Reports. (Rochester, NY) Volume(issue)/page/year: UR-154,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2638 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag, Postfach
860420, D-8000 Munich 86, Fed. Rep. Ger.) V.1- 1946-
Volume(issue)/page/year: 34,484,1979
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983.
For publisher information, see 85KYAH. Volume(issue)/page/year: 11,253,1989
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and
Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia)
No.1- 1993- Volume(issue)/page/year: (7),32,1994
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 44 gm/kg/31D-I
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects
Musculoskeletal - changes in teeth and supporting structures
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and
Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia)
No.1- 1993- Volume(issue)/page/year: (7),32,1994
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 3200 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag, Postfach
860420, D-8000 Munich 86, Fed. Rep. Ger.) V.1- 1946-
Volume(issue)/page/year: 34,124,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 67200 mg/kg
SEX/DURATION : female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag, Postfach
860420, D-8000 Munich 86, Fed. Rep. Ger.) V.1- 1946-
Volume(issue)/page/year: 34,484,1979
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - rat Ascites tumor
DOSE/DURATION : 1 gm/kg
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
54,155,1963
*** REVIEWS ***
ACGIH TLV-TWA 2.5 mg(F)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 2.5 mg(F)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,116,1971
OSHA PEL (Gen Indu):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 2.5 mg(F)/m3 JAN 1993
OEL-BELGIUM:TWA 2.5 mg(F)/m3 JAN 1993
OEL-DENMARK:TWA 2.5 mg(F)/m3 JAN 1993
OEL-FINLAND:TWA 2.5 mg(F)/m3 JAN 1993
OEL-FRANCE:TWA 2.5 mg(F)/m3 JAN 1993
OEL-GERMANY:TWA 2.5 mg(F)/m3 JAN 1993
OEL-HUNGARY:TWA 1 mg(F)/m3;STEL 2 mg(F)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 2.5 mg(F)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 2.5 mg(F)/m3 JAN 1993
OEL-POLAND:TWA 1 mg(F)/m3 JAN 1993
OEL-RUSSIA:STEL 0.5 ppm (2.5 mg/m3) JAN 1993
OEL-SWEDEN:TWA 2 mg(F)/m3 JAN 1993
OEL-SWITZERLAND:TWA 1.8 ppm (1.5 mg(F)/m3);STEL 9.0 ppm JAN 1993
OEL-THAILAND:TWA 2.5 mg(F)/m3 JAN 1993
OEL-TURKEY:TWA 2.5 mg(F)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 2.5 mg(F)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO FLUORIDES, INORGANIC-air:10H TWA 2.5 mg(F)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0579
No. of Facilities: 840 (estimated)
No. of Industries: 17
No. of Occupations: 22
No. of Employees: 17561 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0579
No. of Facilities: 25299 (estimated)
No. of Industries: 187
No. of Occupations: 76
No. of Employees: 344071 (estimated)
No. of Female Employees: 3195 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***