*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EX6800000
CHEMICAL NAME           : Cantharides
SUBSTANCE DEFINITION :
   Active ingredient is cantharidin (0.6%)
REFERENCE :
   27ZTAP "Clinical Toxicology of Commercial Products--Acute Poisoning," 3rd
   ed., Gleason, M.N., et al., eds., Baltimore, Williams and Wilkins, 1969
LAST UPDATED            : 199506
DATA ITEMS CITED        : 1
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Blister beetles
   * Cantharis vesicatoria
   * Spanish fly
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 84 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Gastrointestinal - ulceration or bleeding from stomach
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   AMLTAS Annales de Medecine Legale et de Criminologie.  (Paris, France)
   V.31-38, 1951-58.  For publisher information, see MLDCAS.
   Volume(issue)/page/year: 37,41,1957
 
                            *** END OF RECORD ***