*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EY9275000
CHEMICAL NAME           : Carbamic acid, bis(2-chloropropyl)-, ethyl ester
CAS REGISTRY NUMBER     : 5580-27-8
BEILSTEIN REFERENCE NO. : 4937706
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C9-H17-Cl2-N-O2
MOLECULAR WEIGHT        : 242.17
WISWESSER LINE NOTATION : G3N3GVO2
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Bis(2-chloropropyl)carbamic acid, ethyl ester
   * NSC-53105
   * 6W54
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 405 mg/kg/27D
TOXIC EFFECTS :
   Behavioral - analgesia
   Blood - leukopenia
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 36,77,1964
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 593 mg/kg/18D
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 36,77,1964
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 36,77,1964
 
                            *** END OF RECORD ***