*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EZ9228000
CHEMICAL NAME           : Carbamic acid, dimethyl-,
                          (2-((dimethylamino)methyl)-3-pyridyl) ester,
                          dihydrochloride
CAS REGISTRY NUMBER     : 67049-84-7
LAST UPDATED            : 199703
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C11-H17-N3-O2.2Cl-H
MOLECULAR WEIGHT        : 296.23
WISWESSER LINE NOTATION : T6NJ B1N1&1 COVN1&1 &GH 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Aminostigmin
   * Aminostigmine
   * Dimethylcarbamic acid (2-((dimethylamino)methyl)-3-pyridyl) ester  
   dihydrochloride
   * Ro 2-2126
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 220 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZPKHAB Zhurnal Prikladnoi Khimii (S.-Peterburg).  Journal of Applied
   Chemistry.  (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39  117049 Moscow,
   Russia)  V.1-    1928-  Volume(issue)/page/year: 68,675,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 160 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACSAT Journal of the American Chemical Society.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1879-  Volume(issue)/page/year: 74,3323,1952
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 25,62,1991
 
                            *** END OF RECORD ***