*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FA1070000
CHEMICAL NAME           : Carbamic acid,
                          (((8-beta)-1,6-dimethylergolin-8-yl)methyl)-, benzyl
                          ester
CAS REGISTRY NUMBER     : 17692-51-2
LAST UPDATED            : 199703
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C25-H29-N3-O2
MOLECULAR WEIGHT        : 403.57
WISWESSER LINE NOTATION : T C6656 1A P GN LNTT&&J E1MVO1R& G1 L1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * AHR 3009
   * Carbamic acid, ((1,6-dimethylergolin-8-beta-yl)methyl)-, benzyl ester
   * Carbamic acid, (((8-beta)-1,6-dimethylergolin-8-yl)methyl)-, phenylmethyl 
    ester
   * D-8-beta-((Carbobenzoxyamino)methyl)-1,6-dimethyl-10-alpha-ergoline
   * D-N-Carbobenzoxydihydro-1-methyllysergamine I
   * D-8-beta-((Carboxyamino)methyl)-1,6-dimethylergoline I benzyl ester
   * D-N-Carboxydihydro-1-methyllysergamine I benzyl ester
   * 1,6-Dimethyl-8-beta-carbobenzyloxaminomethyl-10-alpha-ergoline
   * (((8-beta)-1,6-Dimethylergolin-8-yl)methyl)carbamic acid phenylmethyl  
   ester
   * Liserdol
   * Lysergamine, N-carboxy-9,10-dihydro-1-methyl-, benzyl ester
   * MCE
   * Metergolin
   * Metergolina
   * Metergoline
   * Methergoline
   * 1-Methyl-8-beta-carbobenzyloxyaminomethyl-10-alpha-ergoline
   * 1-Methyl-N-carbobenzyloxydihydro-D-lysergamin
   * Substance 355/255
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 430 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 207,421,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 85 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 207,421,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4176182
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 207,421,1965
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 1200 ug/kg
SEX/DURATION            : lactating female 5 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - postpartum
   Reproductive - Maternal Effects - other effects
REFERENCE :
   OBGNAS Obstetrics and Gynecology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1953- Volume(issue)/page/year:
   51,113,1978
 
                            *** END OF RECORD ***