*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FD0575000
CHEMICAL NAME           : Carbamic acid, 2-phenylhydrazide
CAS REGISTRY NUMBER     : 103-03-7
BEILSTEIN REFERENCE NO. : 0743311
REFERENCE               : 4-15-00-00180 (Beilstein Handbook Reference)
LAST UPDATED            : 199707
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C7-H9-N3-O
MOLECULAR WEIGHT        : 151.19
WISWESSER LINE NOTATION : ZVMMR
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 1-Carbamoyl-2-phenylhydrazine
   * Carbaphen
   * Cryogenine (pharmaceutical)
   * Febrimin
   * Fenylsemikarbazid
   * Hydrazine, 1-carbamoyl-2-phenyl-
   * Hydrazinecarboxamide, 2-phenyl-
   * Phenicarbazid
   * Phenicarbazide
   * 2-Phenyldiazenecarboxamide
   * 2-Phenylhydrazide, carbamic acid
   * 1-Phenylhydrazine carboxamide
   * 2-Phenylhydrazinecarboxamide
   * Phenylsemicarbazide
   * 1-Phenylsemicarbazide
   * Semicarbazide, 1-phenyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 198 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,1469,1981
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 394 mg/kg/62W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   52,241,1974
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 250 ug/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 133,161,1984

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Limited Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 12,177,1976

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 12,177,1976

   IARC Cancer Review:Group 3
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***