*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FD1150000
CHEMICAL NAME           : Carbamic acid, 1-(2-propynyl)cyclohexyl ester
CAS REGISTRY NUMBER     : 358-52-1
BEILSTEIN REFERENCE NO. : 3253991
REFERENCE               : 4-06-00-00362 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C10-H15-N-O2
MOLECULAR WEIGHT        : 181.26
WISWESSER LINE NOTATION : L6TJ AOVZ A2UU1
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Carbamate du propinylcyclohexanol
   * 1-Carbamoyloxy-1-(2-propynyl)cyclohexane
   * Cyclohexanol, 1-(2-propynyl)-, carbamate
   * Esapropimato
   * Hexapropymate
   * L-2103
   * LF 62
   * Lunamin
   * Merinax
   * Modirax
   * Propynylcyclohexanol carbamate
   * 1-(2-Propynyl)cyclohexanol carbamate
   * 1-(2-Propynyl)cyclohexyl carbamate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - cyanosis
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   MTAEEB Medical Toxicology and Adverse Drug Experience.  (Adis International
   Ltd., Private Baq 65901, Mairangi Bay, Auckland 10, N.Z.)  V.4-    1989-
   Volume(issue)/page/year: 4,295,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 228 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Vascular - BP lowering not characterized in autonomic section
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   1,1593,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 286 mg/kg/36H-I
TOXIC EFFECTS :
   Behavioral - coma
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   MTAEEB Medical Toxicology and Adverse Drug Experience.  (Adis International
   Ltd., Private Baq 65901, Mairangi Bay, Auckland 10, N.Z.)  V.4-    1989-
   Volume(issue)/page/year: 4,295,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,414,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,414,1972
 
                            *** END OF RECORD ***