*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FD1750000
CHEMICAL NAME           : Carbamic acid, 2,2,2-trichloroethyl ester
CAS REGISTRY NUMBER     : 107-69-7
BEILSTEIN REFERENCE NO. : 1762058
REFERENCE               : 3-03-00-00046 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C3-H4-Cl3-N-O2
MOLECULAR WEIGHT        : 192.43
WISWESSER LINE NOTATION : ZVO1XGGG
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Carbamic acid, 2,2,2-trichloroethyl ester
   * Ethanol, 2,2,2-trichloro-, carbamate
   * Trichloroethyl carbamate
   * Trichlorourethane
   * Voluntal
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   LDTU** "Narkoseversuche mit Hoheren Alkoholen und Stickstoffderivaten,
   Dissertation," Leube, F., Pharmakologischen Institut der Universitat
   Tubingen, Fed. Rep. Ger., 1931  Volume(issue)/page/year: -,-,1931
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   8,99,1947
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3250 mg/kg/13W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   8,99,1947
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 20 umol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,1194,1980
 
                            *** END OF RECORD ***