*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AI9100000
CHEMICAL NAME : Acetic acid, methyl ester
CAS REGISTRY NUMBER : 79-20-9
LAST UPDATED : 199712
DATA ITEMS CITED : 49
MOLECULAR FORMULA : C3-H6-O2
MOLECULAR WEIGHT : 74.09
WISWESSER LINE NOTATION : 1VO1
COMPOUND DESCRIPTOR : Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetate de methyle
* Devoton
* Ethyl ester of monoacetic acid
* Methylacetaat
* Methylacetat
* Methyl acetate
* Methyle (acetate de)
* Methylester kiseliny octove
* Methyl ethanoate
* Metile (acetato di)
* Octan metylu
* Tereton
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,859,1979
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,353,1986
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,353,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 15000 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,859,1979
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 32000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa
Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
Volume(issue)/page/year: 18,45,1943
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 34 gm/m3/4H
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 67 gm/m3/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3705 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year: 41,31,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,859,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraduodenal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,859,1979
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 214 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 33(8),107,1968
** MUTATION DATA **
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 33800 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,339,1985
*** REVIEWS ***
ACGIH TLV-STEL 757 mg/m3 (250 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 606 mg/m3 (200 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 21,28,1960
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 200 ppm (610 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,153,1971
OSHA PEL (Gen Indu):8H TWA 200 ppm (610 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 200 ppm (610 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 200 ppm (610 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 200 ppm (610 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 200 ppm (610 mg/m3);STEL 250 ppm (760 mg/m3) JAN 1993
OEL-BELGIUM:TWA 200 ppm (610 mg/m3);STEL 250 ppm (760 mg/m3) JAN 1993
OEL-DENMARK:TWA 200 ppm (610 mg/m3) JAN 1993
OEL-FINLAND:TWA 200 ppm (610 mg/m3);STEL 250 ppm (765 mg/m3) JAN 1993
OEL-FRANCE:TWA 200 ppm (610 mg/m3);STEL 250 ppm (760 mg/m3) JAN 1993
OEL-GERMANY:TWA 200 ppm (610 mg/m3) JAN 1993
OEL-HUNGARY:TWA 200 mg/m3;STEL 500 mg/m3;Skin JAN 1993
OEL-JAPAN:TWA 200 ppm (610 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 200 ppm (610 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 200 ppm (610 mg/m3) JAN 1993
OEL-POLAND:TWA 100 mg/m3 JAN 1993
OEL-RUSSIA:TWA 200 ppm;STEL 100 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 200 ppm (610 mg/m3);STEL 400 ppm JAN 1993
OEL-TURKEY:TWA 200 ppm (610 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 200 ppm (610 mg/m3);STEL 250 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYL ACETATE-air:10H TWA 200 ppm;STEL 250 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 46410
No. of Facilities: 1604 (estimated)
No. of Industries: 26
No. of Occupations: 22
No. of Employees: 5611 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 46410
No. of Facilities: 387 (estimated)
No. of Industries: 15
No. of Occupations: 31
No. of Employees: 20455 (estimated)
No. of Female Employees: 6018 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Methyl acetate, 1458
*** END OF RECORD ***