*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AJ2900000
CHEMICAL NAME           : Acetic acid, 2-phenylhydrazide
CAS REGISTRY NUMBER     : 114-83-0
BEILSTEIN REFERENCE NO. : 0742880
REFERENCE               : 4-15-00-00163 (Beilstein Handbook Reference)
LAST UPDATED            : 199706
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C8-H10-N2-O
MOLECULAR WEIGHT        : 150.20
WISWESSER LINE NOTATION : 1VMMR
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Tumorigen
                          Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acetic acid phenylhydrazone
   * Acetylphenylhydrazine
   * beta-Acetylphenylhydrazine
   * N-Acetyl-N'-phenylhydrazine
   * 1-Acetyl-2-phenylhydrazine
   * APH
   * Fenylhydrazid kyseliny octove
   * Hydracetin
   * N'-Phenylacethydrazide
   * Pyrodin
   * Pyrodine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 14,162,1980
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 105 mg/kg/7D-I
TOXIC EFFECTS :
   Blood - other changes
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   32,269,1996
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 112 mg/kg/4W-I
TOXIC EFFECTS :
   Blood - methemoglobinemia-carboxyhemoglobin
   Blood - changes in erythrocyte (RBC) count
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - dehydrogenases
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   20,141,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 28 mg/kg/7D-I
TOXIC EFFECTS :
   Blood - pigmented or nucleated red blood cells
   Blood - methemoglobinemia-carboxyhemoglobin
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   32,269,1996
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 31 gm/kg/79W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Vascular - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   39,584,1979
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 333 ug/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11(Suppl 12),1,1988

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83705
       No. of Facilities: 174 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 1744 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83705
       No. of Facilities: 613 (estimated)
       No. of Industries: 20
       No. of Occupations: 19
       No. of Employees: 15429 (estimated)
       No. of Female Employees: 4988 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***