*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AK9275000
CHEMICAL NAME           : Acetohydroxamic acid, fluoren-2-yl-O-glucuronide
CAS REGISTRY NUMBER     : 2495-54-7
LAST UPDATED            : 199007
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H21-N-O9
MOLECULAR WEIGHT        : 431.43
WISWESSER LINE NOTATION : L B656 HHJ F1YQUNQ EOV- BT6OTJ CQ DQ EQ FQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * O-Glucuronide, N-hydroxy-2-acetylaminofluorene
   * N-Hydroxy-2-acetylaminofluorene-O-glucuronide
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 850 mg/kg/9W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   31,1645,1971
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 10 umol/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 72,847,1984
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Mammary gland
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,4227,1988
 
                            *** END OF RECORD ***