*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FH5390000
CHEMICAL NAME           : 5-beta-Card-20(22)-enolide,
                          3-beta,12-beta,14-trihydroxy-
CAS REGISTRY NUMBER     : 1672-46-4
BEILSTEIN REFERENCE NO. : 0096479
REFERENCE               : 5-18-04-00380 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C23-H34-O5
MOLECULAR WEIGHT        : 390.57
WISWESSER LINE NOTATION : L E5 B666TJ A1 DQ E1 F- DT5OV CUTJ IQ OQ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Card-20(22)-enolide, 3,12,14-trihydroxy-, (3-beta,5-beta,12-beta)-
   * Cardogenen-(20:22)-triol-(3-beta,12,14)
   * Digoxigenin
   * Digoxigenine
   * Lanadigenin
   * delta-sup(20:22)-3-beta,12-beta,14,21-Tetrahydroxynorcholenic acid  
   lactone
   * 3-beta,12-beta,14-Trihydroxy-card-20(22)-enolide
   * 3-beta,12,14-Trioxy-carden-(20:22)-olid
   * 3-beta,12,14-Trioxy-digen-(20:22)-olid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 244 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JPHAA3 Journal of the American Pharmaceutical Association.  (Washington, DC)
    V.1-28, 1912-39; New series: V.1-17, 1961-77. Volume(issue)/page/year:
   27,189,1938
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 285 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster,
   Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963  Volume(issue)/page/year:
   -,55,1963
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 3545 ug/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - other changes
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 153,436,1965
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 1620 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 8,18,1960

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster,
   Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963  Volume(issue)/page/year:
   -,190,1963

 
                            *** END OF RECORD ***