*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FI0700000
CHEMICAL NAME           : Carrageen
CAS REGISTRY NUMBER     : 9000-07-1
OTHER CAS REGISTRY NOS. : 78005-48-8
LAST UPDATED            : 199706
DATA ITEMS CITED        : 11
COMPOUND DESCRIPTOR     : Tumorigen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Aubygel GS
   * Aubygum DM
   * Burtonite V-40-E
   * Carastay
   * Carastay C
   * Carrageenan
   * Carrageenan gum
   * Carrageenin
   * Carragheen
   * Carragheenan
   * Colloid 775
   * Coreine
   * Eucheuma spinosum gum
   * Flanogen ELA
   * Galozone
   * Gelcarin
   * Gelcarin HWG
   * Gelozone
   * Genugel
   * Genugel CJ
   * Genugol RLV
   * Genuvisco J
   * Gum carrageenan
   * Gum chon 2
   * Gum chond
   * Killeen
   * Lygomme CDS
   * Norsk gelatan
   * Pearlpuss
   * Pellugel
   * Pellugel ID
   * Pencogel
   * Pig-Wrack
   * Satiagel GS350
   * Satiagum 3
   * Satiagum standard
   * Seakem carrageenin
   * Soa Ace WX 138
   * Viscarin TP 389
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Blood - change in clotting factors
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 17,647,1965
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 202,401,1964
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2100 gm/kg/40W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - colon tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   38,4427,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 525 mg/kg/21W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   13BYAH "Morphological Precursors of Cancer, Proceedings of an International
   Conference, Perugia, Italy, 1961," Severi, L., ed., Perugia, Univ. of
   Perugia, 1962  Volume(issue)/page/year: -,83,1962
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 430 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   15,607,1961
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 32,711,1986

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Limited Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 10,181,1976

   IARC Cancer Review:Group 3
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 84153
       No. of Facilities: 460 (estimated)
       No. of Industries: 7
       No. of Occupations: 11
       No. of Employees: 7864 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 84153
       No. of Facilities: 1064 (estimated)
       No. of Industries: 9
       No. of Occupations: 24
       No. of Employees: 42680 (estimated)
       No. of Female Employees: 17454 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***