*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : FI0700000 CHEMICAL NAME : Carrageen CAS REGISTRY NUMBER : 9000-07-1 OTHER CAS REGISTRY NOS. : 78005-48-8 LAST UPDATED : 199706 DATA ITEMS CITED : 11 COMPOUND DESCRIPTOR : Tumorigen Natural Product SYNONYMS/TRADE NAMES : * Aubygel GS * Aubygum DM * Burtonite V-40-E * Carastay * Carastay C * Carrageenan * Carrageenan gum * Carrageenin * Carragheen * Carragheenan * Colloid 775 * Coreine * Eucheuma spinosum gum * Flanogen ELA * Galozone * Gelcarin * Gelcarin HWG * Gelozone * Genugel * Genugel CJ * Genugol RLV * Genuvisco J * Gum carrageenan * Gum chon 2 * Gum chond * Killeen * Lygomme CDS * Norsk gelatan * Pearlpuss * Pellugel * Pellugel ID * Pencogel * Pig-Wrack * Satiagel GS350 * Satiagum 3 * Satiagum standard * Seakem carrageenin * Soa Ace WX 138 * Viscarin TP 389 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Blood - change in clotting factors REFERENCE : JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 17,647,1965 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 202,401,1964 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2100 gm/kg/40W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - colon tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 38,4427,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 525 mg/kg/21W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : 13BYAH "Morphological Precursors of Cancer, Proceedings of an International Conference, Perugia, Italy, 1961," Severi, L., ed., Perugia, Univ. of Perugia, 1962 Volume(issue)/page/year: -,83,1962 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 430 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 15,607,1961 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 32,711,1986 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,181,1976 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84153 No. of Facilities: 460 (estimated) No. of Industries: 7 No. of Occupations: 11 No. of Employees: 7864 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84153 No. of Facilities: 1064 (estimated) No. of Industries: 9 No. of Occupations: 24 No. of Employees: 42680 (estimated) No. of Female Employees: 17454 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***