*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : FJ5950000
CHEMICAL NAME : Cellulose, carboxymethyl ether, sodium salt
CAS REGISTRY NUMBER : 9004-32-4
LAST UPDATED : 199710
DATA ITEMS CITED : 15
COMPOUND DESCRIPTOR : Tumorigen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* AC-Di-sol. NF
* Aku-W 515
* Aquaplast
* B 10
* B 10 (Polysaccharide)
* Blanose BS 190
* Blanose BWM
* Carbose 1M
* Carboxymethylcellulose, sodium salt
* Carmethose
* Cellofas
* Cellofas B
* Cellofas B5
* Cellofas B6
* Cellofas B50
* Cellofas C
* Cellogel C
* Cellogen 3H
* Cellogen PR
* Cellogen WS-C
* Cellpro
* Cellufix FF 100
* Cellugel
* Cellulose glycolic acid, sodium salt
* Cellulose sodium glycolate
* CMC 2
* CMC 41A
* CM-Cellulose sodium salt
* CMC 7H
* CMC 4H1
* CMC 7H3SF
* CMC 7L1
* CMC 7M
* CMC 4M6
* CMC 7MT
* CMC 3M5T
* CMC sodium salt
* Collowel
* Copagel PB 25
* Courlose A 590
* Courlose A 610
* Courlose A 650
* Courlose F 4
* Courlose F 8
* Courlose F 20
* Courlose F 370
* Courlose F 1000G
* Daicel 1150
* Daicel 1180
* Edifas B
* Ethoxose
* Fine Gum HES
* Glikocel TA
* 7H3SF
* KMTs 212
* KMTs 300
* KMTs 500
* KMTs 600
* Lovosa
* Lovosa 20alk.
* Lovosa TN
* Lucel (polysaccharide)
* Majol PLX
* Modocoll 1200
* NaCm-cellulose salt
* Nymcel S
* Nymcel slc-T
* Nymcel ZSB 10
* Nymcel ZSB 16
* Polyfibron 120
* Sanlose SN 20A
* Sarcell tel
* S 75M
* Sodium carboxmethylcellulose
* Sodium carboxymethyl cellulose
* Sodium cellulose glycolate
* Sodium CMC
* Sodium CM-cellulose
* Sodium glycolate cellulose
* Sodium salt of carboxymethylcellulose
* Tylose 666
* Tylose C
* Tylose C 30
* Tylose C 300
* Tylose C 600
* Tylose CB 200
* Tylose CBR 400
* Tylose CBR series
* Tylose CBS 30
* Tylose CBS 70
* Tylose CB series
* Tylose C 1000P
* Tylose CR
* Tylose CR 50
* Tylose DKL
* Unisol RH
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 27000 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 13,29,1948
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5800 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year:
(Suppl),243,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >27 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam,
Netherlands) V.16-18, 1975-77. Discontinued. Volume(issue)/page/year:
17,351,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >27 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam,
Netherlands) V.16-18, 1975-77. Discontinued. Volume(issue)/page/year:
17,351,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year:
(Suppl),243,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 16000 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 13,29,1948
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 227 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
33,909,1995
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1900 mg/kg/19W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
13BYAH "Morphological Precursors of Cancer, Proceedings of an International
Conference, Perugia, Italy, 1961," Severi, L., ed., Perugia, Univ. of
Perugia, 1962 Volume(issue)/page/year: -,83,1962
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8600 mg/kg/19W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
13BYAH "Morphological Precursors of Cancer, Proceedings of an International
Conference, Perugia, Italy, 1961," Severi, L., ed., Perugia, Univ. of
Perugia, 1962 Volume(issue)/page/year: -,83,1962
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 33 gm/kg/22W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 18,225,1977
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 140 mg/kg
SEX/DURATION : male 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,623,1977
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T1474
No. of Facilities: 13501 (estimated)
No. of Industries: 93
No. of Occupations: 102
No. of Employees: 318345 (estimated)
No. of Female Employees: 184422 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8786
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***