*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : FN0275000 CHEMICAL NAME : Chloramide CAS REGISTRY NUMBER : 10599-90-3 LAST UPDATED : 199701 DATA ITEMS CITED : 10 MOLECULAR FORMULA : Cl-H2-N MOLECULAR WEIGHT : 51.48 WISWESSER LINE NOTATION : ZG COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * Chloramine * Chloramine (inorganic compound) * Chloroamine * Monochloramide * Monochloramine * Monochloroamine * Monochloroammonia *** HEALTH HAZARD DATA *** ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2028 mg/kg/1Y-C TOXIC EFFECTS : Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 13,825,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 170 mg/kg/9W-C TOXIC EFFECTS : Gastrointestinal - other changes Endocrine - changes in spleen weight Biochemical - Metabolism (Intermediary) - lipids including transport REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 44,257,1987 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7280 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-392,1992 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 18 umol/L REFERENCE : SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 192,1141,1976 TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 18 umol/L REFERENCE : SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 192,1141,1976 TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Multiple routes TEST SYSTEM : Non-mammalian species DOSE/DURATION : 150 ppb REFERENCE : MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,170,1989 *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY On EPA IRIS database NTP Carcinogenesis Studies (drinking);equivocal evidence:rat NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-392,92 NTP Carcinogenesis Studies (drinking);no evidence:mouse NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-392,92 *** END OF RECORD ***