*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : FZ2231000
CHEMICAL NAME : 5-beta-Cholan-24-oic acid,
3-alpha,7-alpha-dihydroxy-, monosodium salt
CAS REGISTRY NUMBER : 2646-38-0
LAST UPDATED : 198508
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C24-H39-O4.Na
MOLECULAR WEIGHT : 414.62
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Chenodeoxycholic acid sodium salt
* Chenodesoxycholic acid sodium salt
* Cholan-24-oic acid, 3,7-dihydroxy-, monosodium salt,
(3-alpha,5-beta,7-alpha)-
* Sodium chenodeoxycholate
* Sodium chenodesoxycholate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 11,2499,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1450 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from small intestine
Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 11,2499,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 114 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 11,2499,1977
*** END OF RECORD ***