*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FZ2500000
CHEMICAL NAME           : 5-beta-Cholan-24-oic acid, 3,7,12-trioxo-, sodium
                          salt
CAS REGISTRY NUMBER     : 145-41-5
LAST UPDATED            : 199701
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C24-H33-O5.Na
MOLECULAR WEIGHT        : 424.56
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Biliron
   * Biliton
   * Carachol
   * 5-beta-Cholan-24-oic acid, 3,7,12-trioxo-, monosodium salt
   * Cholan-24-oic acid, 3,7,12-trioxo-, sodium salt, (5-beta)-
   * Decholin sodium
   * Decholin sodium salt
   * Dehydrocholate sodium
   * Dehydrocholic acid, sodium salt
   * Dilabil sodium
   * Dycholium
   * Natriumdehydrocholat
   * Sodium dehydrocholate
   * Sodium 3,7,12-triketocholanate
   * Sodium 3,7,12-trioxo-5-beta-cholanate
   * Sodium 3,7,12-trioxo-5-beta-cholan-24-oate
   * Suprachol
   * Triceto 3-7-12 cholanate de Na
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3755 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GWXXBX German Offenlegungsschrift Patent Document.  (U.S. Patent and
   Trademark Office, Foreign Patents, Washington, DC 20231)
   Volume(issue)/page/year: #2630169
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHTPBA Chimica Therapeutica.  (Paris, France)  V.1-8, 1965-73.  For
   publisher information, see EJMCA5.  Volume(issue)/page/year: 5,188,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2300 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   YOIZA3 Yonago Igaku Zasshi.  Journal of the Yonago Medical Association. (c/o
   Tottori Daigaku Igakabu, 86 Nishi-machi, Yonago, Japan)  V.1-    1948-
   Volume(issue)/page/year: 25,70,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 887 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,280,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2150 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   YOIZA3 Yonago Igaku Zasshi.  Journal of the Yonago Medical Association. (c/o
   Tottori Daigaku Igakabu, 86 Nishi-machi, Yonago, Japan)  V.1-    1948-
   Volume(issue)/page/year: 25,70,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1480 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,280,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1350 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   YOIZA3 Yonago Igaku Zasshi.  Journal of the Yonago Medical Association. (c/o
   Tottori Daigaku Igakabu, 86 Nishi-machi, Yonago, Japan)  V.1-    1948-
   Volume(issue)/page/year: 25,70,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   YOIZA3 Yonago Igaku Zasshi.  Journal of the Yonago Medical Association. (c/o
   Tottori Daigaku Igakabu, 86 Nishi-machi, Yonago, Japan)  V.1-    1948-
   Volume(issue)/page/year: 25,70,1974
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Gastrointestinal - other changes
   Blood - other changes
REFERENCE :
   ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin.  (Berlin, Fed.
   Rep. Ger.)  V.1-139, 1913-65.  For publisher information, see REXMAS.
   Volume(issue)/page/year: 52,779,1926

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***