*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : FZ6360000 CHEMICAL NAME : 5-alpha-Cholestan-3-beta-ol, 5,6-alpha-epoxy- CAS REGISTRY NUMBER : 1250-95-9 BEILSTEIN REFERENCE NO. : 0089511 REFERENCE : 5-17-04-00143 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C27-H46-O2 MOLECULAR WEIGHT : 402.73 WISWESSER LINE NOTATION : T3 F5 E666 1A R AXO CH&TTTTJ IY1&3Y1&1 J1 QQ COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * Cholestan-3-ol, 5,6-epoxy-, (3-beta,5-alpha,6-alpha)- * Cholesterol-alpha-epoxide * Cholesterol 5-alpha,6-alpha-epoxide * Cholesterol oxide * Cholesterol alpha-oxide * 5-alpha,6-alpha-Epoxycholestanol * Epoxycholesterol *** HEALTH HAZARD DATA *** ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 750 mg/kg/9W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 19,977,1957 ** MUTATION DATA ** TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Fibroblast DOSE/DURATION : 10 mg/L/4H REFERENCE : AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 56,287,1978 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Fibroblast DOSE/DURATION : 500 ug/L/4H REFERENCE : AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 56,287,1978 TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - mouse Embryo DOSE/DURATION : 50 umol/L/24H (Continuous) REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 36,2369,1987 TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 625 ug/L REFERENCE : CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 6,143,1979 TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 60 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,355,1988 TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 25 umol/L REFERENCE : FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,1103,1986 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay *** END OF RECORD ***