*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : FZ8170000
CHEMICAL NAME : 5-beta-Cholest-7-en-6-one,
2-beta,3-beta,14,22,25-pentahydroxy-, (20S,22R)-
CAS REGISTRY NUMBER : 3604-87-3
BEILSTEIN REFERENCE NO. : 2422986
REFERENCE : 4-08-00-03613 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C27-H44-O6
MOLECULAR WEIGHT : 464.71
WISWESSER LINE NOTATION : L E5 B666 JUTJ A1 E1 FY1&2YQXQ1&1 IQ OQ PQ
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Cholest-7-en-6-one, 2,3,14,22,25-pentahydroxy-,
(2-beta,3-beta,5-beta,22R)-
* Ecdysone
* alpha-Ecdysone
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Amphibian - toad
DOSE/DURATION : 50 mg/kg/17W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Tumorigenic - tumors at site of application
REFERENCE :
NUCADQ Nutrition and Cancer. (Franklin Institute Press, POB 2266,
Phildelphia, PA 19103) V.1- 1978- Volume(issue)/page/year: 9,103,1987
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 300 umol/L
REFERENCE :
NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246,
1971-73. For publisher information, see NATUAS. Volume(issue)/page/year:
230,222,1971
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 200 ppm
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 30,279,1974
*** END OF RECORD ***