*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FZ8708000
CHEMICAL NAME           : Cholesterol, 7-oxo-
CAS REGISTRY NUMBER     : 566-28-9
BEILSTEIN REFERENCE NO. : 2169084
REFERENCE               : 4-08-00-01048 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C27-H44-O2
MOLECULAR WEIGHT        : 400.71
WISWESSER LINE NOTATION : L E5 B666 KV LUTJ A1 E1 FY1&3Y1&1 OQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Cholest-5-en-7-one, 3-hydroxy-, (3-beta)-
   * Cholest-5-en-7-one, 3-beta-hydroxy-
   * 3-beta-Hydroxycholest-5-en-7-one
   * 7-Ketocholesterol
   * 7-Oxocholesterol
   * SC 4722
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg/9W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   19,977,1957
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 25 umol/L
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   24,1103,1986
 
                            *** END OF RECORD ***