*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : FZ9350000
CHEMICAL NAME : Cholic acid
CAS REGISTRY NUMBER : 81-25-4
BEILSTEIN REFERENCE NO. : 2822009
REFERENCE : 4-10-00-02072 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C24-H40-O5
MOLECULAR WEIGHT : 408.64
WISWESSER LINE NOTATION : L E5 B666TJ A1 DQ E1 FY1&2VQ KQ OQ
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* Cholalin
* Cholan-24-oic acid, 3,7,12-trihydroxy-,
(3-alpha,5-beta,7-alpha,12-alpha)-
* Cholsaeure
* Colalin
* 3,7,12-Trihydroxy-cholan-24-oic acid (3-alpha,5-beta,7-alpha,12-alpha)
* 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-cholan-24-oic acid
* 3-alpha,7-alpha,12-alpha-Trihydroxycholansaeure
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4950 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - ulceration or bleeding from stomach
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:
(103),29,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 330 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,323,1970
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 158,45,1985
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 93200 umol/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
60,192,1987
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 400 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 5,447,1984
TYPE OF TEST : Morphological transformation
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 7560 mg/kg/6W
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 9,387,1988
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84435
No. of Facilities: 174 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1744 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84435
No. of Facilities: 46 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 511 (estimated)
No. of Female Employees: 325 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***