*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GA2360000
CHEMICAL NAME : Choline, chloride, succinate (2:1)
CAS REGISTRY NUMBER : 71-27-2
LAST UPDATED : 199706
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C14-H30-N2-O4.2Cl
MOLECULAR WEIGHT : 361.36
WISWESSER LINE NOTATION : 1K1&1&2OV2VO2K1&1&1 &Q 2 &G 2
COMPOUND DESCRIPTOR : Drug
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Anectine
* Anectine chloride
* Bis(2-dimethylaminoethyl)succinate bis(methochloride)
* Bis(succinyldichlorocholine)
* Chlorsuccinylcholin
* Chlorure de succinilcoline
* Choline succinate dichloride
* Choline, succinyl-, dichloride
* Cloruro di succinilcolina
* Diacetylcholine chloride
* Diacetylcholine dichloride
* 2-Dimethylaminoethyl succinate dimethochloride
* Ethanaminium,
2,2'-((1,4-dioxo-1,4-butanediyl)bis(oxy))bis(N,N,N-trimethyl-, dichloride
* (2-Hydroxyethyl)trimethylammonium chloride succinate
* Lysthenon
* Lysthenone
* Midarine
* Myoplegine
* Pantolax
* Quelicin chloride
* Scoline
* Scoline chloride
* Skolin
* Succicuran
* Succinic acid, bis(beta-dimethylaminoethyl) ester, dimethochloride
* Succinic acid, diester with choline chloride
* Succinoylcholine chloride
* Succinyl-asta
* Succinyl bischoline chloride
* Succinylbischoline dichloride
* Succinylcholine chloride
* Succinylcholine dichloride
* Succinyldicholine chloride
* Succinylforte
* Sucostrin chloride
* Sukcinylcholinchlorid
* Suxamethonium chloride
* Suxamethonium dichloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 1429 ug/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
106,164,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 7 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in potassium
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
AROTAA Archives of Otolaryngology. (AMA, 535 N. Dearborn St., Chicago, IL
60610) V.1-52, 1925-50; V.72- 1960- Volume(issue)/page/year:
96,464,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,135,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 430 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 109,83,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 240 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - rigidity (including catalepsy)
REFERENCE :
IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8,
1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year:
5,305,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 122,152,1959
** MUTATION DATA **
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 300 ug/culture
REFERENCE :
MSCREJ Medical Science Research. (Elsevier Applied Science Pub. Ltd., Crown
House, Linton Rd., Barking, Essex IG11 8JU, UK) V.15- 1987-
Volume(issue)/page/year: 20,759,1992
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 2500 ug/kg
REFERENCE :
MSCREJ Medical Science Research. (Elsevier Applied Science Pub. Ltd., Crown
House, Linton Rd., Barking, Essex IG11 8JU, UK) V.15- 1987-
Volume(issue)/page/year: 20,759,1992
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84013
No. of Facilities: 25 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 400 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84013
No. of Facilities: 207 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 10334 (estimated)
No. of Female Employees: 9106 (estimated)
*** END OF RECORD ***