*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GB3850000
CHEMICAL NAME           : Chromin
CAS REGISTRY NUMBER     : 56257-74-0
OTHER CAS REGISTRY NOS. : 1407-01-8
LAST UPDATED            : 199807
DATA ITEMS CITED        : 5
WISWESSER LINE NOTATION : T C666 BO EVJ FE IR BVQ& LE MQ N-HG-Q
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * C-6
   * Cacaomycin
   * Chromine
   * Khromin
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 30 mg
REACTION SEVERITY       : Severe
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 21(10),35,1977
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 21(10),35,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAJBAD Journal of Antibiotics, Series B.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JJANAX.  Volume(issue)/page/year: 6,247,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CKFRAY Ceskoslovenska Farmacie.  (PNS-Ustredni Expedice a Dovoz Tisku,
   Kafkova 19, 160 00 Prague 6, Czechoslovakia)  V.1-    1952-
   Volume(issue)/page/year: 5,411,1956

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-RUSSIA:STEL 5 mg/m3 JAN 1993

 
                            *** END OF RECORD ***