*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GD0300400
CHEMICAL NAME           : C.I. Fluorescent Brightening Agent 24
CAS REGISTRY NUMBER     : 12224-02-1
OTHER CAS REGISTRY NOS. : 16470-25-0
                          41614-14-6
                          66813-34-1
LAST UPDATED            : 199709
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C40-H40-N12-O16-S4.4Na
MOLECULAR WEIGHT        : 1165.12
WISWESSER LINE NOTATION : T6N CN ENJ BN2Q2Q DMR DSWO FMR CSWO D1U1R BSWO DM-
                          BT6N CN ENJ DN2Q2Q FMR CSWO &-NA- 4
COMPOUND DESCRIPTOR     : Mutagen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Belofor STsD
   * C.I. Fluorescent Brightener 24
   * Heliofor P
   * Kayaphor BSN
   * Mikephor BN
   * Tinopal 2B
   * Tinopal 2BF
   * Whitex BB
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg
REACTION SEVERITY       : Moderate
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1960 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 51(1),87,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1620 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 51(1),87,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13800 mg/kg/30D-I
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Liver - liver function tests impaired
   Blood - change in clotting factors
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 51(1),88,1986

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***