*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GD2425100
CHEMICAL NAME           : C.I. Natural Red 25
CAS REGISTRY NUMBER     : 60687-93-6
LAST UPDATED            : 199801
DATA ITEMS CITED        : 6
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
                          Natural Product
SYNONYMS/TRADE NAMES :
   * C.I. 75450
   * LAC
   * Laccaic acid
   * LAC Dye
   * LAC Lake
   * Natural Red 25
   * Shiko
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 mg/kg/7D-I
TOXIC EFFECTS :
   Liver - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   IJNDAN Indian Journal of Nutrition and Dietetics.  (Sri Avinashilingam Home
   Science College for Women, Coimbatore 641 043, India)  V.7-    1970-
   Volume(issue)/page/year: 17,377,1980
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 18 mg/kg
SEX/DURATION            : multigeneration
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   FACOEB Food Additives and Contaminants.  (Taylor & Francis Inc., 242 Cherry
   St., Philadelphia, PA 19106)  V.1-    1984-  Volume(issue)/page/year:
   14,373,1997
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 2800 mg/kg
REFERENCE :
   IPBHAH Indian Journal of Public Health.  (Indian Public Health Assoc., 110
   Chittaranjan Ave., Calcutta, 700073, India)  V.1-    1957-
   Volume(issue)/page/year: 24,170,1980
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 2800 mg/kg
REFERENCE :
   IPBHAH Indian Journal of Public Health.  (Indian Public Health Assoc., 110
   Chittaranjan Ave., Calcutta, 700073, India)  V.1-    1957-
   Volume(issue)/page/year: 24,170,1980
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1200 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1063 mg/L
REFERENCE :
   SNSHBT Senshokutai.  Chromosome.  (Sensyokutai Gakkai, Kaokusai Kirisutokyo
   Daigaku, Mitaka, Tokyo-to, Japan)  No.1-    1946-    Adopted new numbering
   in 1976.  Volume(issue)/page/year: (20),574,1980
 
                            *** END OF RECORD ***