*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : GD3500000 CHEMICAL NAME : Cinchonine CAS REGISTRY NUMBER : 118-10-5 LAST UPDATED : 199701 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C19-H22-N2-O MOLECULAR WEIGHT : 294.43 WISWESSER LINE NOTATION : T66 BNJ EYQ- DT66 A B CNTJ A1U1 COMPOUND DESCRIPTOR : Drug Natural Product SYNONYMS/TRADE NAMES : * Cinchonan-9-ol, (9S)- * (+)-Cinconine * d-Cinchonine * (8R,9S)-Cinchonine * 2-Quinuclidinemethanol, alpha-4-quinolyl-5-vinyl- * 2-Quinuclidinemethanol, alpha-(5-vinyl-2-quinolyl)- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 152 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - changes in motor activity (specific assay) REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 4,265,1948 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Cardiac - other changes Lungs, Thorax, or Respiration - respiratory depression Blood - other hemolysis with or without anemia REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 205,129,1948 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Amphibian - frog DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Blood - other hemolysis with or without anemia REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 205,129,1948 *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***