*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GE8050000
CHEMICAL NAME : Citric acid, triethyl ester
CAS REGISTRY NUMBER : 77-93-0
BEILSTEIN REFERENCE NO. : 1801199
REFERENCE : 4-03-00-01276 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C12-H20-O7
MOLECULAR WEIGHT : 276.32
WISWESSER LINE NOTATION : 2OV1XQVO2&1VO2
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Citroflex 2
* Ethyl citrate
* NSC 8907
* 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, triethyl ester
* TEC
* Triaethylcitrat
* Triethyl citrate
* Triethylester kyseliny citronove
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5900 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - respiratory depression
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 16,214,1985
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1300 ppm/6H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - pleural effusion
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New
York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year: 2,1892,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - respiratory depression
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 16,214,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6600 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - respiratory depression
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 16,214,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1750 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Vascular - other changes
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 53,774,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 3500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Gastrointestinal - nausea or vomiting
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,389,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,389,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >25 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and
Trademark Office, Foreign Patents, Washington, DC 20231)
Volume(issue)/page/year: #2703360
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4900 mg/kg/14D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 53,774,1964
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 15904 mg/kg/8W-C
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
1,283,1959
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7556
No. of Facilities: 358 (estimated)
No. of Industries: 9
No. of Occupations: 20
No. of Employees: 11496 (estimated)
No. of Female Employees: 3993 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***