*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GG3750000
CHEMICAL NAME : Cobinamide, cyanide phosphate 3'-ester with
5,6-dimethyl-1-alpha-D- ribofuranosylbenzimidazole,
inner salt
CAS REGISTRY NUMBER : 68-19-9
BEILSTEIN REFERENCE NO. : 4122889
LAST UPDATED : 199706
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C63-H88-Co-N14-O14-P
MOLECULAR WEIGHT : 1355.55
WISWESSER LINE NOTATION : D C5656 B-5 B6 B5 S5 J&5 B-19- Q&6 N&5/B-N/DU/J&-M&
J&- O& 9ABBBBCSTT V& AN-CO-&& B-N CN TN C
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Anacobin
* Berubigen
* Betalin-12
* Betalin 12 crystalline
* Betaline-12
* B-Twelve
* B-Twelve ora
* Byladoce
* Cabadon M
* CN-B12
* Cobadoce forte
* Cobalin
* Cobamin
* Cobione
* Cotel
* Covit
* Crystamin
* Crystwel
* Cyano-B12
* Cyanocobalamin
* Cyanocobalamine
* Cycolamin
* Cykobeminet
* Cyredin
* Cytacon
* Cytamen
* Cytobion
* Depinar
* Dimethylbenzimidazoylcobamide
* 5,6-Dimethylbenzimidazolylcobamide cyanide
* Distivit (B12 peptide)
* Dobetin
* Docemine
* Docibin
* Docigram
* Dodecabee
* Dodecavite
* Dodex
* Ducobee
* Duodecibin
* Embiol
* Emociclina
* Eritrone
* Erycytol
* Erythrotin
* Euhaemon
* Extrinsic factor
* Factor II
* Factor II (vitamin)
* Fresmin
* Hemo-B-doze
* Hemomin
* Hepagon
* Hepavis
* Hepcovite
* Lactobacillus lactis dorner factor
* LLD factor
* Macrabin
* Megalovel
* Milbedoce
* Nagravon
* Normocytin
* Pernaemon
* Pernaevit
* Pernipuron
* Plecyamin
* Poyamin
* Rebramin
* Redamina
* Redisol
* Rhodacryst
* Rubesol
* Rubramin
* Rubramin PC
* Rubripca
* Rubrocitol
* Sytobex
* Vibalt
* Vibisone
* Virubra
* Vitamin B12
* Vitamin B12 complex
* Vitamin B12 preparation
* Vitarubin
* Vita-rubra
* Vitral
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 42,114,1992
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1364 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 49,278,1950
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2727 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Blood - other changes
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 49,278,1950
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 115 mg/kg
SEX/DURATION : female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 242,263,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE : 168 mg/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 67,377,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE : 84 mg/kg
SEX/DURATION : female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 67,377,1978
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO COBALT METAL, dust and fume-air:10H TWA 0.05 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80358
No. of Facilities: 1219 (estimated)
No. of Industries: 6
No. of Occupations: 20
No. of Employees: 19601 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80358
No. of Facilities: 3495 (estimated)
No. of Industries: 12
No. of Occupations: 46
No. of Employees: 65178 (estimated)
No. of Female Employees: 27980 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***