*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : GH0882000 CHEMICAL NAME : Colchicine, O(sup 2)-demethyl-10-thio- CAS REGISTRY NUMBER : 87424-26-8 BEILSTEIN REFERENCE NO. : 3176298 REFERENCE : 4-14-00-00957 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C21-H23-N-O5-S MOLECULAR WEIGHT : 401.51 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * 2-Demethylthiocolchicine * O(sup 2)-Demethyl-10-thiocolchicine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 25 ug/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957 *** END OF RECORD ***