*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GK6888000
CHEMICAL NAME           : Concanamycin A,
                          23-O-de(4-O-(aminocarbonyl)-2,6-dideoxy-beta-D-arabin
                          o-hexopyranosyl)-23-O-
                          (4-((2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino)-1,4-di
                          oxo-2-butenyl)-
CAS REGISTRY NUMBER     : 84777-85-5
LAST UPDATED            : 199312
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C48-H71-N-O14
MOLECULAR WEIGHT        : 886.20
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * AM-2604 A
   * Antibiotic AM-2604 A
   * Virustomycin A
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #85859
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 300 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 36,1755,1983
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 30 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 36,1755,1983
 
                            *** END OF RECORD ***