*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GL1224000
CHEMICAL NAME           : Conjugated estrogenic hormones
CAS REGISTRY NUMBER     : 12126-59-9
LAST UPDATED            : 199510
DATA ITEMS CITED        : 6
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Reproductive Effector
                          Human
                          Hormone
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Amnestrogen
   * Climestrone
   * CO-Estro
   * Conest
   * Conestron
   * Conjes
   * Conjugated estrogens
   * Conjutabs
   * Equigyne
   * Estratab
   * Estrifol
   * Estroate
   * Estrocon
   * Estromed
   * Estropan
   * Femacoid
   * Femest
   * FEM H
   * Formatrix
   * Ganeake
   * Genisis
   * Glyestrin
   * Kestrin
   * Menest
   * Menogen
   * Menotab
   * Menotrol
   * Msmed
   * Novoconestron
   * Oestrilin
   * Oestro-feminal
   * Oestropak morning
   * Ovest
   * Palopause
   * Par estro
   * PMB
   * Presomen
   * Promarit
   * SK-Estrogens
   * Sodestrin-H
   * TAG-39
   * Theogen
   * Transannon
   * Trocosone
   * Zeste
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 108 mg/kg/4Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Vascular - tumors
   Liver - tumors
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 137,357,1977
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 27 mg/kg/3Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   NYSJAM New York State Journal of Medicine.  (Medical Soc. of the State of
   New York, POB 5405, Lake Success, NY 11042)  V.1-    1901-
   Volume(issue)/page/year: 78,1933,1978
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 3 mg/kg
SEX/DURATION            : female 1-5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   244,1336,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 4167 ug/kg
SEX/DURATION            : female 1-5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 115,101,1973

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Limited Evidence
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,283,1987

                          *** STATUS IN U.S. ***
 
   NTP 7th Annual Report on Carcinogens, 1992 : known to be carcinogenic

 
                            *** END OF RECORD ***