*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GL1400000
CHEMICAL NAME           : Conopharyngine
CAS REGISTRY NUMBER     : 76-98-2
BEILSTEIN REFERENCE NO. : 0060123
REFERENCE               : 4-25-00-01286 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C23-H30-N2-O4
MOLECULAR WEIGHT        : 398.55
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 18-Carbomethoxy-12,13-dimethoxyibogamine
   * Conopharyngine (iboga)
   * Ibogamine-18-carboxylic acid, 12,13-dimethoxy-, methyl ester
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 30,173,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 143 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 30,173,1967
 
                            *** END OF RECORD ***