*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GL5325000
CHEMICAL NAME : Copper
CAS REGISTRY NUMBER : 7440-50-8
OTHER CAS REGISTRY NOS. : 72514-83-1
LAST UPDATED : 199712
DATA ITEMS CITED : 78
MOLECULAR FORMULA : Cu
MOLECULAR WEIGHT : 63.54
COMPOUND DESCRIPTOR : Tumorigen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Allbri natural copper
* ANAC 110
* Arwood copper
* Bronze powder
* CDA 101
* CDA 102
* CDA 110
* CDA 122
* C.I. 77400
* C.I. Pigment Metal 2
* Copper
* Copper-airborne
* Copper bronze
* Copper-milled
* Copper slag-airborne
* Copper slag-milled
* 1721 Gold
* Gold bronze
* Kafar copper
* M 1
* M 3
* M 4
* M1 (Copper)
* M2 (Copper)
* M3 (Copper)
* M4 (Copper)
* M3R
* M3S
* OFHC Cu
* Raney copper
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 120 ug/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year:
73,910,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2A,1623,1981
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intrapleural
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Lungs, Thorax, or Respiration - tumors
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
41,836,1980
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 152 mg/kg
SEX/DURATION : female 22 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 45(3),8,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1520 ug/kg
SEX/DURATION : female 22 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 45(3),8,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1210 ug/kg
SEX/DURATION : female 35 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 42(8),30,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intrauterine
SPECIES OBSERVED : Rodent - rat
DOSE : 250 ug/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 19,1124,1981
*** REVIEWS ***
ACGIH TLV-TWA 1 mg(Cu)/m3, dust, mist
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.2 mg(Cu)/m3, fume
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX) V.1-41(2),
1943-81/82. Discontinued. Volume(issue)/page/year: 33,85,1975
TOXICOLOGY REVIEW
QURBAW Quarterly Reviews of Biophysics. (Cambridge Univ. Press, The
Edinburgh Bldg., Shaftesbury Rd., Cambridge CB2 2RU, UK) V.1- 1968-
Volume(issue)/page/year: 7,75,1974
TOXICOLOGY REVIEW
JAVMA4 Journal of the American Veterinary Medical Association. (American
Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48-
1915- Volume(issue)/page/year: 164,277,1974
TOXICOLOGY REVIEW
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013,
Israel) V.1- 1965- Volume(issue)/page/year: 10,416,1974
TOXICOLOGY REVIEW
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai
Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku,
Tokyo 107, Japan) V.1- 1965- Volume(issue)/page/year: 11,1300,1975
TOXICOLOGY REVIEW
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942
TOXICOLOGY REVIEW
MIBUBI Mikrobiyoloji Bulteni. Bulletin of Microbiology. (c/o Dr. A. Tevfik
Cenqiz, Ankara Universitesi Tip Fakultesi Mikrobiyoloji Ana Bilim Dah,
Ankara, Turkey) V.1- 1967- Volume(issue)/page/year: 9,321,1975
TOXICOLOGY REVIEW
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year:
12,102,1969
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Cu,41,1977
TOXICOLOGY REVIEW
AMTODM Advances in Modern Toxicology. (John Wiley & Sons, Inc., 605 Third
Ave., New York, NY 10016) V.1, 1976-79. Discontinued.
Volume(issue)/page/year: 3,209,1977
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 0.1 mg/m3 (fume,dusts & mists)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,59,1971
OSHA PEL (Gen Indu):8H TWA 0.1 mg(Cu)/m3, fume
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Gen Indu):8H TWA 1 mg(Cu)/m3, dusts and mists
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.1 mg(Cu)/m3, fume
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Construc):8H TWA 1 mg(Cu)/m3, dusts and mists
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.1 mg(Cu)/m3, fume
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 1 mg(Cu)/m3, dusts and mists
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.1 mg/m3, fume
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
OSHA PEL (Fed Cont):8H TWA 1 mg/m3, dusts and mists
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.1 mg/m3 (fume) JAN 1993
OEL-AUSTRALIA:TWA 0.2 mg/m3 (fume) JAN 1993
OEL-AUSTRALIA:TWA 1 mg/m3 (dust) JAN 1993
OEL-BELGIUM:TWA 0.2 mg/m3 (fume) JAN 1993
OEL-BELGIUM:TWA 1 mg/m3 (dust) JAN 1993
OEL-DENMARK:TWA 0.1 mg/m3 (fume) JAN 1993
OEL-DENMARK:TWA 1 mg/m3 (dust) JAN 1993
OEL-FINLAND:TWA 0.2 mg/m3 (fume) JAN 1993
OEL-FINLAND:TWA 1 mg/m3 (dust) JAN 1993
OEL-FRANCE:TWA 0.2 mg/m3 (fume) JAN 1993
OEL-FRANCE:TWA 1 mg/m3;STEL 2 mg/m3 (dust) JAN 1993
OEL-GERMANY:TWA 0.1 mg/m3 (fume) JAN 1993
OEL-GERMANY:TWA 1 mg/m3 (dust) JAN 1993
OEL-HUNGARY:TWA 0.2 mg/m3;STEL 0.4 mg/m3 (dust) JAN 1993
OEL-INDIA:TWA 0.2 mg/m3 (fume) JAN 1993
OEL-THE NETHERLANDS:TWA 02 mg/m3 (fume) JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg/m3 (dust) JAN 1993
OEL-THE PHILIPPINES:TWA 1.0 mg/m3 (fume) JAN 1993
OEL-POLAND:TWA 0.1 mg/m3 (fume) JAN 1993
OEL-RUSSIA:STEL 0.5 ppm (1 mg/m3) (dust) JAN 1993
OEL-SWEDEN:TWA 0.2 mg/m3 (resp. dust) JAN 1993
OEL-SWEDEN:TWA 0.2 mg/m3 (fume) JAN 1993
OEL-SWEDEN:TWA 1 mg/m3 (total dust) JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg/m3;STEL 0.2 mg/m3 (fume) JAN 1993
OEL-SWITZERLAND:TWA 1 mg/m3;STEL 1 mg/m3 JAN 1993
OEL-THAILAND:TWA 0.1 mg/m3 (fume) JAN 1993
OEL-THAILAND:TWA 1 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.2 mg/m3 (fume) JAN 1993
OEL-UNITED KINGDOM:TWA 1 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO COPPER, dusts and mists-air:10H TWA 1 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO COPPER, fume-air:10H TWA 0.1 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2276
No. of Facilities: 1213 (estimated)
No. of Industries: 27
No. of Occupations: 35
No. of Employees: 24737 (estimated)
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 20115
No. of Facilities: 12177 (estimated)
No. of Industries: 176
No. of Occupations: 105
No. of Employees: 224406 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5915
No. of Facilities: 162 (estimated)
No. of Industries: 5
No. of Occupations: 5
No. of Employees: 11889 (estimated)
No. of Female Employees: 421 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5983
No. of Facilities: 4558 (estimated)
No. of Industries: 51
No. of Occupations: 45
No. of Employees: 53282 (estimated)
No. of Female Employees: 8758 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6807
No. of Facilities: 16 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 625 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X8588
No. of Facilities: 204 (estimated)
No. of Industries: 3
No. of Occupations: 7
No. of Employees: 9443 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 20115
No. of Facilities: 59839 (estimated)
No. of Industries: 296
No. of Occupations: 158
No. of Employees: 920449 (estimated)
No. of Female Employees: 72821 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Copper (dust and fume), 7029
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
OSHA ANALYTICAL METHOD #ID-125G
*** END OF RECORD ***