*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GL7375000
CHEMICAL NAME           : Copper,
                          (5-((4'-((2,5-dihydroxy-4-((2-hydroxy-5-sulfophenyl)a
                          zo)phenyl)azo)(1,1'-b iphenyl)-
                          4-yl)azo)-2-hydroxybenzoato(2-))-, disodium salt
CAS REGISTRY NUMBER     : 16071-86-6
LAST UPDATED            : 199712
DATA ITEMS CITED        : 23
MOLECULAR FORMULA       : C31-H18-Cu-N6-O9-S.2Na
MOLECULAR WEIGHT        : 760.13
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Aizen Primula Brown BRLH
   * Aizen Primula Brown PLH
   * Amanil Fast Brown BRL
   * Amanil Supra Brown LBL
   * Atlantic Fast Brown BRL
   * Atlantic Resin Fast Brown BRL
   * Belamine Fast Brown BRLL
   * Benzamil Supra Brown BRLL
   * Benzanil Supra Brown BRLN
   * Brown 4EMBL
   * Calcodur Brown BRL
   * Chloramine Fast Brown BRL
   * Chloramine Fast Brown BRLL
   * Chloramine Fast Cutch Brown PL
   * Chrome Leather Brown BRLL
   * Chrome Leather Brown BRSL
   * C.I. 30145
   * C.I. Direct Brown
   * Cuprofix Brown GL
   * Derma Fast Brown W-GL
   * Dermafix Brown PL
   * Dialuminous Brown BRS
   * Diaphtamine Light Brown BRLL
   * Diazine Fast Brown RSL
   * Diazol Light Brown BRN
   * Dicorel Brown LMR
   * Diphenyl Fast Brown BRL
   * Direct Brown 95
   * Direct Brown BRL
   * Direct Fast Brown BRL
   * Direct Fast Brown LMR
   * Direct Light Brown BRS
   * Direct Supra Light Brown ML
   * Durazol Brown BR
   * DuroFast Brown BRL
   * Eliamina Light Brown BRL
   * Enianil Light Brown BRL
   * Fastolite Brown BRL
   * Fastusol Brown LBRSA
   * Fastusol Brown LBRSN
   * Fenaluz Brown BRL
   * Helion Brown BRSL
   * Hispaluz Brown BRL
   * Hned prima 95
   * Kayarus Supra Brown BRS
   * Kca Light Fast Brown BR
   * NCI-C54568
   * Paranol Fast Brown BRL
   * Peeramine Fast Brown BRL
   * Pontamine Fast Brown BRL
   * Pontamine Fast Brown NP
   * Pyrazol Fast Brown BRL
   * Pyrazoline Brown BRL
   * Saturn Brown LBR
   * Sirius Supra Brown BRL
   * Sirius Supra Brown BRS
   * Solantine Brown BRL
   * Solar Brown PL
   * Solex Brown R
   * Solius Light Brown BRLL
   * Solius Light Brown BRS
   * Sumilight Supra Brown BRS
   * Suprazo Brown BRL
   * Suprexcel Brown BRL
   * Tertrodirect Fast Brown BR
   * Tetramine Fast Brown BRDN Extra
   * Tetramine Fast Brown BRP
   * Tetramine Fast Brown BRS
   * Triantine Brown BRS
   * Triantine Fast Brown OG
   * Triantine Fast Brown OR
   * Triantine Light Brown BRS
   * Triantine Light Brown OG
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12060 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TSCAT* Office of Toxic Substances Report.  (U.S. Environmental Protection
   Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
   Volume(issue)/page/year: OTS 215154
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TSCAT* Office of Toxic Substances Report.  (U.S. Environmental Protection
   Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
   Volume(issue)/page/year: OTS 215154
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2625 mg/kg/5W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-108,1978
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6825 mg/kg/13W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   54,431,1980
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 nmol
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 136,33,1984
 
TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 136,147,1984
 
TYPE OF TEST            : Body fluid assay
TEST SYSTEM             : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION           : 250 umol/kg
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 31,271,1984

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Limited Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 29,321,1982

   IARC Cancer Review:Animal Sufficient Evidence
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,125,1987

   IARC Cancer Review:Human Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 29,321,1982

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-FINLAND;Carcinogen JAN 1993
   
   OEL-FRANCE;Carcinogen JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M1412
       No. of Facilities: 37 (estimated)
       No. of Industries: 3
       No. of Occupations: 11
       No. of Employees: 1112 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M1412
       No. of Facilities: 119 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 830 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   On EPA IRIS database
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NIOSH CURRENT INTELLIGENCE BULLETIN 24, 1978
   
   NIOSH Analytical Method, 1994: Dyes, 5013
   
   NCI Carcinogenesis Bioassay (feed);clear evidence:rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-108,78

   NCI Carcinogenesis Bioassay (feed);no evidence:mouse
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-108,78

   NTP Toxicity studies, RPT# TR-108, October 1997

 
                            *** END OF RECORD ***