*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : GL7375000 CHEMICAL NAME : Copper, (5-((4'-((2,5-dihydroxy-4-((2-hydroxy-5-sulfophenyl)a zo)phenyl)azo)(1,1'-b iphenyl)- 4-yl)azo)-2-hydroxybenzoato(2-))-, disodium salt CAS REGISTRY NUMBER : 16071-86-6 LAST UPDATED : 199712 DATA ITEMS CITED : 23 MOLECULAR FORMULA : C31-H18-Cu-N6-O9-S.2Na MOLECULAR WEIGHT : 760.13 COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * Aizen Primula Brown BRLH * Aizen Primula Brown PLH * Amanil Fast Brown BRL * Amanil Supra Brown LBL * Atlantic Fast Brown BRL * Atlantic Resin Fast Brown BRL * Belamine Fast Brown BRLL * Benzamil Supra Brown BRLL * Benzanil Supra Brown BRLN * Brown 4EMBL * Calcodur Brown BRL * Chloramine Fast Brown BRL * Chloramine Fast Brown BRLL * Chloramine Fast Cutch Brown PL * Chrome Leather Brown BRLL * Chrome Leather Brown BRSL * C.I. 30145 * C.I. Direct Brown * Cuprofix Brown GL * Derma Fast Brown W-GL * Dermafix Brown PL * Dialuminous Brown BRS * Diaphtamine Light Brown BRLL * Diazine Fast Brown RSL * Diazol Light Brown BRN * Dicorel Brown LMR * Diphenyl Fast Brown BRL * Direct Brown 95 * Direct Brown BRL * Direct Fast Brown BRL * Direct Fast Brown LMR * Direct Light Brown BRS * Direct Supra Light Brown ML * Durazol Brown BR * DuroFast Brown BRL * Eliamina Light Brown BRL * Enianil Light Brown BRL * Fastolite Brown BRL * Fastusol Brown LBRSA * Fastusol Brown LBRSN * Fenaluz Brown BRL * Helion Brown BRSL * Hispaluz Brown BRL * Hned prima 95 * Kayarus Supra Brown BRS * Kca Light Fast Brown BR * NCI-C54568 * Paranol Fast Brown BRL * Peeramine Fast Brown BRL * Pontamine Fast Brown BRL * Pontamine Fast Brown NP * Pyrazol Fast Brown BRL * Pyrazoline Brown BRL * Saturn Brown LBR * Sirius Supra Brown BRL * Sirius Supra Brown BRS * Solantine Brown BRL * Solar Brown PL * Solex Brown R * Solius Light Brown BRLL * Solius Light Brown BRS * Sumilight Supra Brown BRS * Suprazo Brown BRL * Suprexcel Brown BRL * Tertrodirect Fast Brown BR * Tetramine Fast Brown BRDN Extra * Tetramine Fast Brown BRP * Tetramine Fast Brown BRS * Triantine Brown BRS * Triantine Fast Brown OG * Triantine Fast Brown OR * Triantine Light Brown BRS * Triantine Light Brown OG *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 12060 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 215154 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 215154 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2625 mg/kg/5W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors REFERENCE : NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-108,1978 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6825 mg/kg/13W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 54,431,1980 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 100 nmol REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,33,1984 TYPE OF TEST : Unscheduled DNA synthesis ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 100 mg/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,147,1984 TYPE OF TEST : Body fluid assay TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium DOSE/DURATION : 250 umol/kg REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 31,271,1984 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,321,1982 IARC Cancer Review:Animal Sufficient Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,125,1987 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,321,1982 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1412 No. of Facilities: 37 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 1112 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1412 No. of Facilities: 119 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 830 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies On EPA IRIS database EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NIOSH CURRENT INTELLIGENCE BULLETIN 24, 1978 NIOSH Analytical Method, 1994: Dyes, 5013 NCI Carcinogenesis Bioassay (feed);clear evidence:rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-108,78 NCI Carcinogenesis Bioassay (feed);no evidence:mouse NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-108,78 NTP Toxicity studies, RPT# TR-108, October 1997 *** END OF RECORD ***