*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GM7925000
CHEMICAL NAME           : Corticotropin-releasing factor (sheep), 2-L-glutamic
                          acid-22-L-alanine-23-L-arginine- 25-L-glutamic
                          acid-38-L-methionine-39-L-glutamic
                          acid-41-L-isoleucinamide-
CAS REGISTRY NUMBER     : 86784-80-7
LAST UPDATED            : 199510
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C208-H344-N60-O63-S2
MOLECULAR WEIGHT        : 4758.24
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Corticobiss
   * Corticotropin-releasing factor (horse)
   * Corticotropin-releasing factor (human)
   * Corticotropin-releasing factor (rat)
   * Corticotropin-releasing hormone (human)
   * CRF 41
   * Human corticotropin-releasing factor
   * Human corticotropin-releasing hormone
   * Human corticotropin-releasing hormone-41
   * Human CRF
   * Human CRF (1-41)
   * MCI 028
   * Rat ACTH-releasing hormone
   * Rat corticotropin-releasing factor
   * Rat corticotropin-releasing factor-41
   * Rat CRF
   * Rat CRF(1-41)
   * Rat hypothalamic CRF
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 20(Suppl 5),S1241,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >1 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 20(Suppl 5),S1241,1992
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 560 ug/kg/4W-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Blood - changes in spleen
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 20(Suppl 5),S1263,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 840 ug/kg/4W-I
TOXIC EFFECTS :
   Endocrine - changes in adrenal weight
   Endocrine - changes in thymus weight
   Related to Chronic Data - changes in uterine weight
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 20(Suppl 5),S1287,1992
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1148 ug/kg
SEX/DURATION            : male 9 week(s) pre-mating
                          female 2 week(s) pre-mating  - 7 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 20(Suppl 5),S1313,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3111 ug/kg
SEX/DURATION            : male 61 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 20(Suppl 5),S1313,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2700 ug/kg
SEX/DURATION            : female 17-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 20(Suppl 5),S1349,1992
 
                            *** END OF RECORD ***