*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GN4900000
CHEMICAL NAME           : Coumarin, 3-(alpha-acetonyl-p-nitrobenzyl)-4-hydroxy-
CAS REGISTRY NUMBER     : 152-72-7
LAST UPDATED            : 199504
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C19-H15-N-O6
MOLECULAR WEIGHT        : 353.35
WISWESSER LINE NOTATION : T66 BOVJ DY1V1&R DNW& EQ
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Acenocoumarin
   * Acenocoumarol
   * Acenocumarol
   * Acenokumarin
   * 3-(alpha-Acetonyl-p-nitrobenzyl)-4-hydroxy-coumarin
   * 3-(alpha-Acetonyl-4-nitrobenzyl)-4-hydroxycoumarin
   * Ascumar
   * 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-
   * G-23350
   * 4-Hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-2H-1-benzopyran-2-one
   * Nicoumalone
   * 3-(alpha-(p-Nitrophenol)-beta-acetylethyl)-4-hydroxycoumarin
   * Nitrophenylacetylethyl-4-hydroxycoumarine
   * 3-(alpha-p-Nitrophenyl-beta-acetylethyl)-4-hydroxycoumarin
   * 3-(alpha-(4'-Nitrophenyl)-beta-acetylethyl)-4-hydroxycoumarin
   * Nitrovarfarian
   * Nitrowarfarin
   * Sincoumar
   * Sinkumar
   * Sinthrom
   * Sinthrome
   * Sintrom
   * Sintroma
   * Syncoumar
   * Syncumar
   * Syntrom
   * Zotil
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 513 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,3,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1470 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 11,85,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 115 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,6,1989
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 24 mg/kg
SEX/DURATION            : female 1-28 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   AFPEAM Archives Francaises de Pediatrie.  (Doin Editeurs, 8, Place de
   l'Odeon, F-75006 Paris, France) V.1-    1942-  Volume(issue)/page/year:
   36,63,1979

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X7380
       No. of Facilities: 8 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 239 (estimated)
       No. of Female Employees: 157 (estimated)

 
                            *** END OF RECORD ***