*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : GN4978000 CHEMICAL NAME : Coumarin, 3,3'-(p-chlorobenzylidene)bis(4-hydroxy- CAS REGISTRY NUMBER : 4322-59-2 LAST UPDATED : 199512 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C25-H15-Cl-O6 MOLECULAR WEIGHT : 446.85 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * 3,3'-(p-Chlorobenzylidene)bis(4-hydroxycoumarin) * 3,3'-(p-Chlorobenzylideno)-bis-4-hydroksykumaryn * PCBD *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 820 mg/kg TOXIC EFFECTS : Cardiac - other changes Vascular - BP lowering not characterized in autonomic section REFERENCE : DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 17,163,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 158 mg/kg TOXIC EFFECTS : Cardiac - other changes Vascular - BP lowering not characterized in autonomic section REFERENCE : DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 17,163,1965 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Cardiac - other changes Vascular - BP lowering not characterized in autonomic section REFERENCE : DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 17,163,1965 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 221 mg/kg/7D-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 17,163,1965 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 110 mg/kg/11D-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 17,163,1965 *** END OF RECORD ***