*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GN6300000
CHEMICAL NAME           : Coumarin, 3-chloro-7-hydroxy-4-methyl-, O-ester with
                          O,O-diethyl phosphorothioate
CAS REGISTRY NUMBER     : 56-72-4
BEILSTEIN REFERENCE NO. : 0327083
REFERENCE               : 4-18-00-00344 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 28
MOLECULAR FORMULA       : C14-H16-Cl-O5-P-S
MOLECULAR WEIGHT        : 362.78
WISWESSER LINE NOTATION : T66 BOVJ DG E1 IOPS&O2&O2
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Agridip
   * Asunthol
   * Asuntol
   * Azunthol
   * BAY 21/199
   * Bayer 21/199
   * Baymix
   * Baymix 50
   * 3-Chloro-7-hydroxy-4-methyl-coumarin O,O-diethyl phosphorothioate
   * 3-Chloro-7-hydroxy-4-methyl-coumarin O-ester with O,O-diethyl  
   phosphorothioate
   * 3-Chloro-4-methyl-7-coumarinyl diethyl phosphorothioate
   * O-3-Chloro-4-methyl-7-coumarinyl O,O-diethyl phosphorothioate
   * 3-Chloro-4-methyl-7-hydroxycoumarin diethyl thiophosphoric acid ester
   * 3-Chloro-4-methylumbelliferone O-ester with O,O-diethyl phosphorothioate
   * CO-Ral
   * Coumafos
   * Coumaphos
   * Cumafos
   * O,O-Diaethyl-O-(3-chlor-4-methyl-cumarin-7-yl)-monothiophosphat
   * O,O-Diethyl-O-(3-chloor-4-methyl-cumarin-7-yl)monothiofosfaat
   * O,O-Diethyl O-(3-chloro-4-methyl-7-coumarinyl)phosphorothioate
   * O,O-Diethyl O-(3-chloro-4-methylcoumarinyl-7) thiophosphate
   * O,O-Diethyl  
   O-(3-chloro-4-methyl-2-oxo-2H-benzopyran-7-yl)phosphorothioate
   * O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate
   * O,O-Diethyl O-(3-chloro-4-methylumbelliferyl)phosphorothioate
   * Diethyl 3-chloro-4-methylumbelliferyl thionophosphate
   * Diethyl thiophosphoric acid ester of 3-chloro-4-methyl-7-hydroxycoumarin
   * O,O-Dietil-O-(3-cloro-4-metil-cumarin-7-il-monotiofosfato)
   * Diolice
   * ENT 17,957
   * Meldane
   * Meldone
   * Muscatox
   * NCI-C08662
   * Negashunt
   * Phosphorothioic acid, O,O-diethyl ester, O-ester with  
   3-chloro-7-hydroxy-4-methylcoumarin
   * Resistox
   * Resitox
   * Suntol
   * Thiophosphate de O,O-diethyle et de O-(3-chloro-4-methyl-7-coumarinyle)
   * Umbethion
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DOEAAH Down to Earth.  (Dow Chemical USA, Agricultural Products Dept.,
   Midland, MI 48640) V.1-    1945-  Volume(issue)/page/year: 35,25,1979
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 303 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VHTODE Veterinary and Human Toxicology.  (American College of Veterinary and
   Comparative Toxicology, Publication Office, Comparative Toxicology,
   Manhattan, KS 66506)  V.19-    1977-  Volume(issue)/page/year: 24,87,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 860 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 129,699,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-71. Discontinued.  Volume(issue)/page/year:
   33(10-12),334,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 11,91,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-71. Discontinued.  Volume(issue)/page/year:
   33(10-12),334,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VHTODE Veterinary and Human Toxicology.  (American College of Veterinary and
   Comparative Toxicology, Publication Office, Comparative Toxicology,
   Manhattan, KS 66506)  V.19-    1977-  Volume(issue)/page/year: 24,87,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2600 ug/kg
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   AJOPAA American Journal of Ophthalmology.  (Ophthalmic Pub. Co., 435 N.
   Michigan Ave., Suite 1415, Chicago, IL 60611)  Series 3: V.1-    1918-
   Volume(issue)/page/year: 53,512,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 58 mg/kg
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-71. Discontinued.  Volume(issue)/page/year:
   33(10-12),334,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCOC** Pesticide Chemicals Official Compendium, Association of the American
   Pesticide Control Officials, Inc., 1966.  (Topeka, KS)
   Volume(issue)/page/year: -,282,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 5620 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ASTTA8 ASTM Special Technical Publication.  (American Soc. for Testing
   Materials, 1916 Race St., Philadelphia, PA 19103)  No.1-    1911-
   Volume(issue)/page/year: (680),157,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : 13300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ASTTA8 ASTM Special Technical Publication.  (American Soc. for Testing
   Materials, 1916 Race St., Philadelphia, PA 19103)  No.1-    1911-
   Volume(issue)/page/year: (680),157,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - duck
DOSE/DURATION           : 29800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DOEAAH Down to Earth.  (Dow Chemical USA, Agricultural Products Dept.,
   Midland, MI 48640) V.1-    1945-  Volume(issue)/page/year: 35,25,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 22600 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - other changes
REFERENCE :
   AJVRAH American Journal of Veterinary Research.  (American Veterinary
   Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196)  V.1-    1940-
   Volume(issue)/page/year: 41,1857,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
   New York, Inc., 1971  Volume(issue)/page/year: -,341,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 1780 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ASTTA8 ASTM Special Technical Publication.  (American Soc. for Testing
   Materials, 1916 Race St., Philadelphia, PA 19103)  No.1-    1911-
   Volume(issue)/page/year: (680),157,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 7500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   26,154,1973
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 168 mg/kg/28W-I
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-71. Discontinued.  Volume(issue)/page/year:
   33(10-12),334,1968
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 1400 ng/plate
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,190,1981

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   AQMOAC Air Quality Monographs.  (Washington, DC)  No.69-1 - No.75-25,
   1969-75(?).  Discontinued.  Volume(issue)/page/year: #73-19,1973

   TOXICOLOGY REVIEW
   RREVAH Residue Reviews.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1962-  Volume(issue)/page/year:
   46,1,1973

   TOXICOLOGY REVIEW
   PMDCAY Progress in Medical Chemistry.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1961- Volume(issue)/page/year:
   10,85,1974

   TOXICOLOGY REVIEW
   RREVAH Residue Reviews.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1962-  Volume(issue)/page/year:
   63,1,1976

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
   FEREAC Federal Register.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402) V.1-    1936-  Volume(issue)/page/year:
   54,7740,1989

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
   
   On EPA IRIS database
   
   NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-96,79

 
                            *** END OF RECORD ***