*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GN7525000
CHEMICAL NAME : Coumarin, 7-hydroxy-4-methyl-, O-ester with
O,O-diethyl phosphorothioate
CAS REGISTRY NUMBER : 299-45-6
BEILSTEIN REFERENCE NO. : 0307407
REFERENCE : 4-18-00-00343 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C14-H17-O5-P-S
MOLECULAR WEIGHT : 328.34
WISWESSER LINE NOTATION : T66 BOVJ E1 IOPS&O2&O2
COMPOUND DESCRIPTOR : Agricultural Chemical
SYNONYMS/TRADE NAMES :
* Bayer E-838
* O,O-Diaethyl-O-(4-methyl-coumarin-7-yl)-monothiophosphat
* Diethoxy thiophosphoric acid ester of 7-hydroxy-4-methyl coumarin
* O,O-Diethyl O-(2-keto-4-methyl-7-alpha',beta'-benzo-alpha'-pyranyl)
thiophosphate
* O,O-Diethyl-O-(4-methylcoumarin-7-yl)-monothiofosfaat
* O,O-Diethyl O-(4-methyl-7-coumarinyl) phosphorothioate
* O,O-Diethyl O-(4-methyl-7-coumarinyl) thionophosphate
* Diethyl methylcoumarinyl thiophosphate
* O,O-Diethyl O-(4-methylcoumarinyl-7) thiophosphate
* O,O-Diethyl-O-(4-methyl-7-kumarinyl) ester kyseliny thiofosforescne
* O,O-Diethyl O-(4-methylumbelliferone) ester of thiophosphoric acid
* O,O-Diethyl O-(4-methylumbelliferone) phosphorothioate
* Diethyl (4-methylumbelliferyl) thionophosphate
* O,O-Dietil-O-(4-metilcumarin-7-il)-monotiofosfato
* O,O-Dietyl-O-4-methylkumarinyl(7)tiofosfat
* E 834
* E 838
* ENT 17,296
* Farbenfabriken bayer
* 7-Hydroxy-4-methylcoumarin, O,O-diethyl thiophosphoric acid ester
* 7-Hydroxy-4-methylcoumarin, O-ester with O,O-diethyl phosphorothioate
* Hymecromone O,O-diethyl phosphorothioate
* 4-Methyl-7-hydroxycoumarin diethoxythiophosphate
* 4-Methylumbelliferone-O,O-diethyl thiophosphate
* Phosphorothioic acid, O,O-diethyl ester, O-ester with
7-hydroxy-4-methylcoumarin
* Phosphorothioic acid, O,O-diethyl O-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)
ester
* Potasan
* Potasan-G-liquid
* Thiophosphate de O,O-diethyle et de O-(4-methyl-7-coumarinyle)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1169,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,9,1952
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 19 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,340,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 99 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 105,156,1952
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1949- Volume(issue)/page/year: 11,636,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71.
Discontinued. Volume(issue)/page/year: 9,119,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 105,156,1952
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 16800 ug/kg/8W-C
TOXIC EFFECTS :
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 105,156,1952
*** REVIEWS ***
TOXICOLOGY REVIEW
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year:
10,85,1974
*** END OF RECORD ***