*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GO5950000
CHEMICAL NAME : Cresol
CAS REGISTRY NUMBER : 1319-77-3
OTHER CAS REGISTRY NOS. : 8026-94-6
BEILSTEIN REFERENCE NO. : 0506719
REFERENCE : 4-06-00-02035 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 44
MOLECULAR FORMULA : C7-H8-O
MOLECULAR WEIGHT : 108.15
WISWESSER LINE NOTATION : QR X1
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Human
SYNONYMS/TRADE NAMES :
* Acede cresylique
* Bacillol
* Cresol
* Cresoli
* Hydroxytoluole
* Kresole
* Kresolen
* Krezol
* Methylphenol
* Phenol, methyl-
* RCRA waste number U052
* Tekresol
* ar-Toluenol
* Tricresol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 177 mg/kg
TOXIC EFFECTS :
Blood - other hemolysis with or without anemia
Blood - other changes
REFERENCE :
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB
8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year:
130,1319,1984
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 114 mg/kg
TOXIC EFFECTS :
Vascular - other changes
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
11,404,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1454 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB214-270
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSGZA3 Kyushu Shika Gakkai Zasshi. Journal of the Kyushu Dental Society.
(c/o Kyushu Shika Daigaku, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Japan)
V.1- 1933- Suspended 1941-50. Volume(issue)/page/year: 36,932,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
42,417,1977
*** REVIEWS ***
ACGIH TLV-TWA 22 mg/m3 (5 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD:skin 5 ppm (22 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,61,1971
OSHA PEL (Gen Indu):8H TWA 5 ppm (22 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 5 ppm (22 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 5 ppm (22 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 5 ppm (22 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 5 ppm (23 mg/m3) JAN 1993
OEL-AUSTRALIA:TWA 5 ppm (22 mg/m3);Skin JAN 1993
OEL-BELGIUM:TWA 5 ppm (22 mg/m3);Skin JAN 1993
OEL-DENMARK:TWA 5 ppm (22 mg/m3);Skin JAN 1993
OEL-FINLAND:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin JAN 1993
OEL-FRANCE:TWA 5 ppm (22 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 5 ppm (22 mg/m3);Skin JAN 1993
OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993
OEL-INDIA:TWA 5 ppm (22 mg/m3);Skin JAN 1993
OEL-JAPAN:TWA 5 ppm (22 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 5 ppm (22 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 5 ppm (22 mg/m3);Skin JAN 1993
OEL-POLAND:TWA 5 mg/m3 JAN 1993
OEL-RUSSIA:TWA 5 ppm;STEL 0.5 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin JAN 1993
OEL-TURKEY:TWA 5 ppm (22 mg/m3);Skin JAN 1993
OEL-UNITED KINGDOM:TWA 5 ppm (22 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CRESOL, all isomers-air:10H TWA 2.3 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 20380
No. of Facilities: 8215 (estimated)
No. of Industries: 86
No. of Occupations: 78
No. of Employees: 71952 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 20380
No. of Facilities: 7461 (estimated)
No. of Industries: 84
No. of Occupations: 65
No. of Employees: 132742 (estimated)
No. of Female Employees: 28184 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Cresol (all isomers) and phenol, 2546
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Toxicity studies, RPT# TOX-09, October 1997
NTP Carcinogenesis studies; selected, October 1997
OSHA ANALYTICAL METHOD #32
*** END OF RECORD ***