*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : GO7100000 CHEMICAL NAME : m-Cresol, 4-chloro- CAS REGISTRY NUMBER : 59-50-7 BEILSTEIN REFERENCE NO. : 1237629 REFERENCE : 4-06-00-02064 (Beilstein Handbook Reference) LAST UPDATED : 199710 DATA ITEMS CITED : 15 MOLECULAR FORMULA : C7-H7-Cl-O MOLECULAR WEIGHT : 142.59 WISWESSER LINE NOTATION : QR DG C COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * Aptal * Baktol * Baktolan * Candaseptic * p-Chlor-m-cresol * Chlorocresol * p-Chloro-m-cresol * 4-Chloro-m-cresol * 4-Chloro-3-methylphenol * 3-Methyl-4-chlorophenol * Ottafact * Parol * PCMC * Peritonan * Phenol, 4-chloro-3-methyl- * Preventol CMK * Raschit * Raschit K * Rasen-Anicon * RCRA waste number U039 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1830 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SchP## Personal Communication from P. Schmitz, Bayer AG, 5090 Leverkusen, Bayerwerk, Fed. Rep. Ger., April 4, 1986 Volume(issue)/page/year: 04APR1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 12,212,1939 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949- Volume(issue)/page/year: 36(1-4),10,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 360 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - tremor Lungs, Thorax, or Respiration - other changes REFERENCE : QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 12,212,1939 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 70 mg/kg TOXIC EFFECTS : Behavioral - coma Lungs, Thorax, or Respiration - other changes REFERENCE : QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 12,212,1939 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 11200 mg/kg/28D-I TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 37,651,1986 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 25 ug/plate REFERENCE : TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981- Volume(issue)/page/year: 14,143,1987 TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 100 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,141,1994 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84772 No. of Facilities: 29 (estimated) No. of Industries: 2 No. of Occupations: 12 No. of Employees: 876 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84772 No. of Facilities: 5608 (estimated) No. of Industries: 65 No. of Occupations: 62 No. of Employees: 175929 (estimated) No. of Female Employees: 24335 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies On EPA IRIS database EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 *** END OF RECORD ***