*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GO7100000
CHEMICAL NAME           : m-Cresol, 4-chloro-
CAS REGISTRY NUMBER     : 59-50-7
BEILSTEIN REFERENCE NO. : 1237629
REFERENCE               : 4-06-00-02064 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 15
MOLECULAR FORMULA       : C7-H7-Cl-O
MOLECULAR WEIGHT        : 142.59
WISWESSER LINE NOTATION : QR DG C
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Aptal
   * Baktol
   * Baktolan
   * Candaseptic
   * p-Chlor-m-cresol
   * Chlorocresol
   * p-Chloro-m-cresol
   * 4-Chloro-m-cresol
   * 4-Chloro-3-methylphenol
   * 3-Methyl-4-chlorophenol
   * Ottafact
   * Parol
   * PCMC
   * Peritonan
   * Phenol, 4-chloro-3-methyl-
   * Preventol CMK
   * Raschit
   * Raschit K
   * Rasen-Anicon
   * RCRA waste number U039
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1830 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SchP## Personal Communication from P. Schmitz, Bayer AG, 5090 Leverkusen,
   Bayerwerk, Fed. Rep. Ger., April 4, 1986  Volume(issue)/page/year: 04APR1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   12,212,1939
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
   C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
   Cancer, 4-1 Seiryo-machi, Sendai, Japan)  V.1-   1949-
   Volume(issue)/page/year: 36(1-4),10,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - tremor
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   12,212,1939
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   12,212,1939
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11200 mg/kg/28D-I
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 37,651,1986
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 25 ug/plate
REFERENCE :
   TECSDY Toxicological and Environmental Chemistry.  (Gordon & Breach Science
   Pub. Inc., 1 Park Ave., New York, NY 10016)  V.3(3/4)-    1981-
   Volume(issue)/page/year: 14,143,1987
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 307,141,1994

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
   FEREAC Federal Register.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402) V.1-    1936-  Volume(issue)/page/year:
   54,7740,1989

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 84772
       No. of Facilities: 29 (estimated)
       No. of Industries: 2
       No. of Occupations: 12
       No. of Employees: 876 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 84772
       No. of Facilities: 5608 (estimated)
       No. of Industries: 65
       No. of Occupations: 62
       No. of Employees: 175929 (estimated)
       No. of Female Employees: 24335 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   On EPA IRIS database
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***