*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GO7300000
CHEMICAL NAME           : o-Cresol,
                          4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-
CAS REGISTRY NUMBER     : 86-42-0
BEILSTEIN REFERENCE NO. : 0300962
REFERENCE               : 5-22-10-00283 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C20-H22-Cl-N3-O
MOLECULAR WEIGHT        : 355.90
WISWESSER LINE NOTATION : T66 BNJ EMR DQ C1N2&2& IG
COMPOUND DESCRIPTOR     : Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * Amodiaquin
   * Amodiaquine
   * Cam-AQ1
   * Camochin
   * Camoquin
   * Camoquinal
   * Camoquine
   * 7-Chloro-4-(3-diethylaminomethyl-4-hydroxyanilino)quinoline
   * 7-Chloro-4-(3-diethylaminomethyl-4-hydroxyphenylamino)quinoline
   * 4-((7-Chloro-4-quinolinyl)amino)-2-((diethylamino)methyl)phenol
   * 4-((7-Chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-cresol
   * Flavoquine
   * Miaquin
   * SN 10,751
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 72 mg/kg/7W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - pulmonary emboli
   Liver - other changes
   Blood - agranulocytosis
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   292,721,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 20 mg/kg/25D-I
TOXIC EFFECTS :
   Blood - thrombocytopenia
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   105,467,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 29 mg/kg/25D-I
TOXIC EFFECTS :
   Blood - thrombocytopenia
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   105,467,1986
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 100,408,1950
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 25,823,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 25,823,1970
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 222,311,1989
 
                            *** END OF RECORD ***